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Wittig reaction
| Wittig reaction | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Named after | Georg Wittig | ||||||||||
| Reaction type | Coupling reaction | ||||||||||
| Reaction | |||||||||||
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| Conditions | |||||||||||
| Typical solvents | typically THF or diethyl ether | ||||||||||
| Identifiers | |||||||||||
| March's Advanced Organic Chemistry | 16–44 (6th ed.) | ||||||||||
| Organic Chemistry Portal | wittig-reaction | ||||||||||
| RSC ontology ID | RXNO:0000015 
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The Wittig reaction or Wittig olefination is a chemical reaction of an aldehyde or ketone with a triphenyl phosphonium ylide called a Wittig reagent. Wittig reactions are most commonly used to convert aldehydes and ketones to alkenes.[1][2][3] Most often, the Wittig reaction is used to introduce a methylene group using methylenetriphenylphosphorane (Ph3P=CH2). Using this reagent, even a sterically hindered ketone such as camphor can be converted to its methylene derivative.
- ^ Maercker, A. Org. React. 1965, 14, 270–490.
- ^ W. Carruthers, Some Modern Methods of Organic Synthesis, Cambridge University Press, Cambridge, UK, 1971, 81–90. (ISBN 0-521-31117-9)
- ^ R. W. Hoffmann (2001). "Wittig and His Accomplishments: Still Relevant Beyond His 100th Birthday". Angewandte Chemie International Edition. 40 (8): 1411–1416. doi:10.1002/1521-3773(20010417)40:8<1411::AID-ANIE1411>3.0.CO;2-U. PMID 11317288.
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