Etoposido

Etoposido
Formula kimikoa	C29H32O13
SMILES kanonikoa	2D eredua
SMILES isomerikoa	C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
MolView	3D eredua
Mota	[[(5S,5aR,8aR,9R)-5-[(7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one|(5S,5aR,8aR,9R)-5-[(7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one]] (en) eta [[(8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one|(8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one]] (en)
Estereoisomeroa	[[(5S,5aS,8aS,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one|(5S,5aS,8aS,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one]] (en)
Masa molekularra	588,184 Da
Erabilera
Konposatu aktiboa	Toposar (en) eta Etopophos (en)
Tratatzen du	Neuroblastoma, testicular cancer (en) , garuneko minbizi, mikosi fungoide, trophoblastic neoplasm (en) , Ewingen sarkoma, histiozitosi, lung benign neoplasm (en) , prostatako minbizi, umetokiko minbizi, Kaposiren sarkoma, acute myeloid leukemia (en) , errabdomiosarkoma, maxkuriko minbizi, linfoma, germ cell cancer (en) , B-cell lymphoma (en) , ez-Hodgkin linfoma, testicular malignant germ cell cancer (en) , Hezur sarkoma, neuroblastoma, susceptibility to (en) , diffuse large B-cell lymphoma (en) , testicular cancer (en) eta lung small cell carcinoma (en)
Interakzioak	ziklosporina
Elkarrekintza	DNA topoisomerase II alpha (en)
Hartzeko bidea	intravenous infusion and defusion (en) eta oral administration (en)
Haurdunaldia	Australian pregnancy category D (en) eta US pregnancy category D (en)
Rola	DNA polymerase inhibitors (en) , topoisomerase inhibitor (en) , phytogenic antineoplastic agents (en) , topoisomerase II inhibitor (en) , developmental toxicant (en) , kantzerigeno eta farmako esentzial
Identifikatzaileak
InChlKey	VJJPUSNTGOMMGY-MRVIYFEKSA-N
CAS zenbakia	33419-42-0
ChemSpider	33510
PubChem	36462
Gmelin	4911
ChEMBL	CHEMBL44657
EC zenbakia	251-509-1
ECHA	100.046.812
MeSH	D005047
RxNorm	4179
Human Metabolome Database	HMDB0014911
UNII	6PLQ3CP4P3
NDF-RT	N0000146478
KEGG	C01576 eta D00125
PDB Ligand	EVP

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Etoposidoa, VP-16 bezala ere ezaguna, podofilina erdisintetiko bat da, Podophyllum landaretik eratorria. Tumore-zelulen ugalketa inhibitzeko duen gaitasunagatik minbizi mota batzuk tratatzeko erabiltzen dute.

Banaketa azkarreko zelula osasuntsu batzuetan ere eragin dezake, hala nola odolaren, digestio-aparatuaren edo ilearen zeluletan, eta, beraz, albo-ondorio kaltegarriak ere sortzen ditu.

Etoposidoa 1983an merkaturatu zuten.^[1]

1. ↑ (Ingelesez) Fischer, Janos; Ganellin, C. Robin. (2006). Analogue-based Drug Discovery. John Wiley & Sons, 489 or. ISBN 9783527607495..