MyD88

MYD88
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	2JS7, 2Z5V, 3MOP, 4DOM, 4EO7
Identifiants
Aliases	MYD88
IDs externes	OMIM: 602170 MGI: 108005 HomoloGene: 1849 GeneCards: MYD88
Position du gène (Homme)
Chr.	Chromosome 3 humain
Fin	38,143,022 bp
Position du gène (Souris)
Chr.	Chromosome 9 (souris)
Fin	119,170,477 bp
Expression génétique
	Fortement exprimé dans
	leucocyte; ; mononuclear cell; ; monocyte; ; granulocyte; ; sang; ; gingival epithelium; ; mucosa of ileum; ; ligament alvéolo-dentaire; ; nasal epithelium; ; palpebral conjunctiva;
	Fortement exprimé dans
	granulocyte; ; stroma of bone marrow; ; lobe pulmonaire droit; ; lèvre; ; articulation talo-crurale; ; utérus; ; œsophage; ; tibiofemoral joint; ; sang; ; duodénum;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	death receptor binding; liaison protéique; TIR domain binding; identical protein binding; protein self-association; Toll-like receptor binding;
Composant cellulaire	cytosol; membrane plasmique; endosome membrane; cytoplasme; noyau;
Processus biologique	response to interleukin-1; processus du système immunitaire; negative regulation of apoptotic process; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; cell surface receptor signaling pathway; cellular response to mechanical stimulus; regulation of inflammatory response; positive regulation of interleukin-6 production; positive regulation of I-kappaB kinase/NF-kappaB signaling; toll-like receptor 9 signaling pathway; positive regulation of interleukin-17 production; réponse inflammatoire; 3'-UTR-mediated mRNA stabilization; positive regulation of type I interferon production; positive regulation of interleukin-23 production; transduction de signal; defense response to Gram-positive bacterium; positive regulation of NF-kappaB transcription factor activity; apoptose; système immunitaire inné; type I interferon signaling pathway; positive regulation of gene expression; positive regulation of interleukin-8 production; defense response to bacterium; interleukin-1-mediated signaling pathway; cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of cytokine production involved in inflammatory response; phagocytose; Toll signaling pathway;
	Sources:Amigo / QuickGO
Orthologues
	4615
	17874
	ENSG00000172936
	ENSMUSG00000032508
	Q99836
	P22366
NM_001172566; NM_001172567; NM_001172568; NM_001172569; NM_002468;
	NM_001365876; NM_001365877; NM_001374787; NM_001374788
	NM_010851
NP_001166037; NP_001166038; NP_001166039; NP_001166040; NP_002459;
	NP_001352805; NP_001352806; NP_001361716; NP_001361717
	NP_034981
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

La réponse primaire de différenciation myéloïde 88 (MYD88) ou, en anglais myeloid differentiation primary response 88, est une protéine qui, chez l’homme, est codée par le gène MYD88^[5]^,^[6]. Elle est impliquée dans la voie de transduction de la voie de signalisation des Toll-like receptors (récepteurs de type Toll) chez les vertébrés.

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000172936 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000032508 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Entrez Gene: MYD88 Myeloid differentiation primary response gene (88) »
↑ « The cloning and characterization of human MyD88: a member of an IL-1 receptor related family », FEBS Letters, vol. 402, n^o 1,‎ janvier 1997, p. 81–4 (PMID 9013863, DOI 10.1016/S0014-5793(96)01506-2)

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000172936 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000032508 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[entrez-5] « Entrez Gene: MYD88 Myeloid differentiation primary response gene (88) »

[pmid9013863-6] « The cloning and characterization of human MyD88: a member of an IL-1 receptor related family », FEBS Letters, vol. 402, n^o 1,‎ janvier 1997, p. 81–4 (PMID 9013863, DOI 10.1016/S0014-5793(96)01506-2)

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MyD88

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