Manitol

D-Manitol

(IUPAC) ime
(2R,3R,4R,5R)-Heksan-1,2,3,4,5,6-heksol
Klinički podaci
AHFS/Drugs.com	Monografija
Identifikatori
CAS broj	69-65-8
ATC kod	A06AD16 B05BC01 B05CX04 R05CB16
PubChem[1][2]	6251
DrugBank	DB00742
ChemSpider[3]	6015
UNII	3OWL53L36A Y
KEGG[4]	D00062 Y
ChEBI	CHEBI:16899 Y
ChEMBL[5]	CHEMBL689 Y
Hemijski podaci
Formula	C6H14O6
Mol. masa	182,172
SMILES	eMolekuli & PubHem
InChI InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1 Y Key: FBPFZTCFMRRESA-KVTDHHQDSA-N Y
Farmakokinetički podaci
Bioraspoloživost	~7%
Metabolizam	Hepatički, zanemarljiv.
Poluvreme eliminacije	100 minuta
Izlučivanje	Renalno: 90%
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	IV Oralno

Manitol je beli, kristalni^[6] šećerni alkohol sa hemijskom formulom (C₆H₈(OH)₆). On se koristi kao osmotički diuretički agens i slab renalni vazodilatator. On je originalno bio izolovan iz sekreta crnog jasena.^[7] On se u biljkama koristi za indukovanje osmotskog stresa.

1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
4. ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
5. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
6. ↑ Lawson, P. In In Mannitol; Blackwell Publishing Ltd: 2007; pp 219-225.
7. ↑ Cooley's Cyclopaedia of Practical Receipts, 6th ed. (1880)