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Metotreksat
| |
| |
| (IUPAC) ime | |
|---|---|
| (2S)-2-[(4[(2,4-diamino-7,8-dihydropteridin-6-yl)methyl](methyl)amino | |
| Klinički podaci | |
| Identifikatori | |
| ATC kod | ? |
| Hemijski podaci | |
| Formula | ? |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
phenyl)formamido]pentanedioic acid
| bioavailability = 17–90% | metabolism = hepatički | elimination_half-life = 3–15 sati | excretion = renalno 48–100% | pregnancy_AU = D | pregnancy_US = X | pregnancy_category = | legal_AU = S4 | legal_UK =POM | legal_US =Rx-only | routes_of_administration = oralno, IV, IM, supkutano, intratekalno
| ATC_prefix=L01 | ATC_suffix=BA01 | ATC_supplemental=L04AX03 | PubChem=126941 | DrugBank=APRD00353 | CAS_number = 59-05-2 | CASNo_Ref = ? | ChemSpiderID = 112728
| C=20 | H=22 | N=8 | O=5
| molecular_weight = 454.44 g/mol
| smiles =
| StdInChI = 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
| StdInChIKey_Ref = 
| StdInChI_comment =
| StdInChIKey = FBOZXECLQNJBKD-ZDUSSCGKSA-N
| StdStdInChI_Ref =
| density =
| melting_point =
| melting_high =
| melting_notes =
| boiling_point =
| boiling_notes =
| solubility =
| specific_rotation =
| sec_combustion =
}}
Metotreksat, Methotrexate (INN), MTX, i bivše poznat kao ametopterin, je antimetabolit i antifolatni lek koji se koristi u tretmanu raka, autoimunih bolesti i za pobačaj.[1] Ovaj lek dejstvuje putem inhibiranja metabolizma folne kiseline. Metotreksat je počeo da zamenjuje snažniji i toksičniji antifolat aminopterin početkom 1950-tih godina.
- ↑ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3.
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