Testosteron

Testosteron
(IUPAC) ime
	(8R,9S,10R,13S,14S,17S)- 17-hidroksi-10,13-dimetil- 1,2,6,7,8,9,11,12,14,15,16,17- dodekahidrociklopenta[a]fenantren-3-on
Klinički podaci
Identifikatori
CAS broj	58-22-0 ; 57-85-2 (propionatni estar)
ATC kod	G03BA03
PubChem	6013
DrugBank	DB00624
ChemSpider	5791
UNII	3XMK78S47O
KEGG	D00075
ChEMBL	CHEMBL386630
Hemijski podaci
Formula	C19H28O2
Mol. masa	288.42
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 ; Key: MUMGGOZAMZWBJJ-DYKIIFRCSA-N
Fizički podaci
Tačka topljenja	155–156 °C (311–313 °F)
Spec. rot	+110,2°
Entalpija gorenja	−11080 kJ/mol
Farmakokinetički podaci
Bioraspoloživost	niska (usled ekstenzivnog metabolizama prvog prolaza)
Metabolizam	Jetra, testis i prostata
Poluvreme eliminacije	2-4 sata
Izlučivanje	Urin (90%), izmet (6%)
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Raspopre III (SAD); Raspored IV (Kanada)
Način primene	Intramuskularne injekcije, transdermalno (krema, gel)

Testosteron je važan seksualni hormon (androgen) koji postoji kod oba pola, ali se razlikuje u količinama i koncentraciji. Testosteron je prvi pronašao i dao mu ime Ernst Laker (fr. Ernst Laqueur).

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[1]

[2]

[3]

[4]

[5]

Our website is made possible by displaying online advertisements to our visitors. Please consider supporting us by disabling your ad blocker.

Testosteron

Our website is made possible by displaying online advertisements to our visitors.
Please consider supporting us by disabling your ad blocker.