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Dobutamin
-Dobutamine_Enantiomers_Struct._Formulae.png)
{{Drugbox-lat | verifiedrevid = 459442789 | IUPAC_name = (RS)-4-(2-{[4-(4-hidroksifenil)butan-2-il]amino}etil)benzen-1,2-diol | image = Dobutamine skeletal.svg | width = | image2 = | width2 = | drug_name = Dobutamin
| tradename = | Drugs.com = Monografija | MedlinePlus = a682861 | pregnancy_category = B | legal_status = Rx-only | routes_of_administration = Intravenozno
| bioavailability = | protein_bound = | metabolism = | elimination_half-life = 2 minuta
| CAS_number_Ref = 
| CAS_number = 34368-04-2
| ATC_prefix = C01
| ATC_suffix = CA07
| ATC_supplemental =
| PubChem = 36811
| IUPHAR_ligand = 535
| DrugBank_Ref =
| DrugBank = DB00841
| ChemSpiderID_Ref =
| ChemSpiderID = 33786
| UNII_Ref =
| UNII = 0WR771DJXV
| KEGG_Ref =
| KEGG = D03879
| ChEBI_Ref =
| ChEBI = 4670
| ChEMBL_Ref =
| ChEMBL = 926
| C=18 | H=23 | N=1 | O=3
| molecular_weight = 301,38 g/mol
| smiles = Oc1ccc(cc1O)CCNC(C)CCc2ccc(O)cc2
| StdInChI_Ref =
| StdInChI = 1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3
| StdInChIKey_Ref =
| StdInChIKey = JRWZLRBJNMZMFE-UHFFFAOYSA-N
| synonyms = Dobutrex, Inotrex
}}
Dobutamin je simpatomimetik koji se koristi u tretmanu zatajenja srca i kardiogenog šoka. Njegov primarni mehanizam je direktna stimulacija β1 receptora simpatičkog nervnog sistema. Ilaj Lili end kompani je razvila dobutamin. On je strukturni analog izoprenalina.[1]
- ^ Tuttle RR, Mills J (1975). „Dobutamine: development of a new catecholamine to selectively increase cardiac contractility”. Circ Res. 36 (1): 185—96. PMID 234805. doi:10.1161/01.RES.36.1.185.
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