Klindamicin

Klindamicin

Klinički podaci
Prodajno ime	Chlolincocin, Cleocin, Cleocin Hcl, Cleocin Pediatric
Drugs.com	Monografija
Način primene	Oralno, Intravaginalnono, topikalno, intramaskularno, intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	2,4 h
Izlučivanje	Urinom
Identifikatori
CAS broj	18323-44-9 Y
ATC kod	D10AF01 (WHO), J01FF01
PubChem	CID 29029
DrugBank	DB01190 Y
ChemSpider	27005 Y
KEGG	C06914 Y
ChEBI	CHEBI:3745 Y
ChEMBL	CHEMBL187 Y
Hemijski podaci
Formula	C18H33ClN2O5S
Molarna masa	424,983
SMILES CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC(C(C)Cl)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O
InChI InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9?,10-,11+,12?,13+,14-,15-,16-,18-/m1/s1 Y Key:KDLRVYVGXIQJDK-NOWPCOIGSA-N Y
Fizički podaci
Tačka topljenja	142 °C (288 °F)

Klindamicin je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 424,983 Da.^{[1][2][3][4][5][6]}

1. ^ Daum RS: Clinical practice. Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N Engl J Med. 2007 Jul 26;357(4):380-90. PMID 17652653
2. ^ Klempner MS, Styrt B: Clindamycin uptake by human neutrophils. J Infect Dis. 1981 Nov;144(5):472-9. PMID 6171600
3. ^ Lamont RF: Can antibiotics prevent preterm birth--the pro and con debate. BJOG. 2005 Mar;112 Suppl 1:67-73. PMID 15715599
4. ^ Plaisance KI, Drusano GL, Forrest A, Townsend RJ, Standiford HC: Pharmacokinetic evaluation of two dosage regimens of clindamycin phosphate. Antimicrob Agents Chemother. 1989 May;33(5):618-20. PMID 2751277
5. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
6. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.  уреди