The 1980 United States presidential election in Missouri took place on November 4, 1980. All 50 states and the District of Columbia were part of the election. Voters chose 12 electors to the Electoral College, who voted for president and vice president.
The state was ultimately carried by Republican Ronald Reagan, who won 51.16% of the vote and went on to be elected president. Missouri continued its bellwether streak, having voted for the eventual presidential winner every election year since 1904, with the sole exception of the 1956 election.