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Anti-neutrophil cytoplasmic antibody

Perinuclear staining typical of p-ANCA
The granular, cytoplasmic staining pattern of c-ANCA
Immunofluorescence staining pattern of ANCA. Top left – PR3 antibodies on ethanol-fixed neutrophils (c-ANCA pattern). Bottom left – PR3 antibodies on formalin-fixed neutrophils(c-ANCA pattern). Top right – MPO antibodies on ethanol-fixed neutrophils (p-ANCA pattern). Bottom right – MPO antibodies on formalin-fixed neutrophils (c-ANCA pattern).(FITC conjugate)

Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the cytoplasm of neutrophils (the most common type of white blood cell) and monocytes. They are detected as a blood test in a number of autoimmune disorders, but are particularly associated with systemic vasculitis, so called ANCA-associated vasculitides (AAV).[1]

  1. ^ Sharma P, Zonozi R, Geetha D (2024). "ANCA-Associated Vasculitis". Advances in Kidney Disease and Health. 31 (3): 194–205. doi:10.1053/j.akdh.2024.04.005. PMID 39004459.

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أجسام مضادة سيتوبلازمية مضادة للعدلات Arabic Anticossos anti antígens citoplasmàtics dels neutròfils Catalan Anti-Neutrophile cytoplasmatische Antikörper German Αντιουδετεροφιλικά αντισώματα Greek Anticuerpos anticitoplasma de neutrófilos Spanish Anticorps anticytoplasme des polynucléaires neutrophiles French Anticorpi anti-citoplasma dei neutrofili Italian 抗好中球細胞質抗体 Japanese Antineutrofiele cytoplasmatische antistoffen Dutch Przeciwciała przeciw cytoplazmie neutrofilów Polish

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