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Chemical ligation
 | This article includes a list of general references, but it lacks sufficient corresponding inline citations. (December 2020) |
Chemical ligation is the chemoselective condensation of unprotected peptide segments enabled by the formation of a non-native bond at the ligation site.
Chemical ligation is usually carried out in aqueous solution. Multiple consecutive chemical ligation reactions can be used to make proteins of the typical size found in Nature, i.e. with polypeptide chains containing 200–300 amino acids, produced by total synthesis.
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