Fibronectin

FN1
Available structures PDB Ortholog search: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB List of PDB id codes 1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6, 1TTF, 1TTG, 2CG6, 2CG7, 2CK2, 2CKU, 2EC3, 2FN2, 2FNB, 2GEE, 2H41, 2H45, 2HA1, 2OCF, 2RKY, 2RKZ, 2RL0, 3CAL, 3EJH, 3GXE, 3M7P, 3MQL, 3R8Q, 3ZRZ, 4GH7, 4JE4, 4JEG, 4LXO, 4MMX, 4MMY, 4MMZ, 4PZ5, 2N1K, 5DC4, 5DC0, 5DC9, 3T1W
Identifiers
Aliases	FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF
External IDs	OMIM: 135600; MGI: 95566; HomoloGene: 1533; GeneCards: FN1; OMA:FN1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 215,360,440 bp[1] End 215,436,073 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 36.05 cM Start 71,624,679 bp[2] End 71,692,359 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint right coronary artery decidua Descending thoracic aorta synovial membrane ascending aorta tibia tendon of biceps brachii stromal cell of endometrium left coronary artery Top expressed in calvaria stroma of bone marrow tunica media of zone of aorta umbilical cord left lung lobe ankle tail of embryo tibiofemoral joint endothelial cell of lymphatic vessel atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding collagen binding integrin binding protein binding identical protein binding peptidase activator activity protease binding Cellular component blood microparticle extracellular matrix fibrinogen complex extracellular region basement membrane apical plasma membrane extracellular exosome platelet alpha granule lumen endoplasmic reticulum-Golgi intermediate compartment extracellular fluid Biological process regulation of protein phosphorylation calcium-independent cell-matrix adhesion endodermal cell differentiation positive regulation of fibroblast proliferation positive regulation of substrate-dependent cell migration, cell attachment to substrate platelet degranulation extracellular matrix disassembly wound healing positive regulation of peptidase activity peptide cross-linking cell adhesion positive regulation of gene expression acute-phase response angiogenesis positive regulation of cell population proliferation regulation of cell shape regulation of ERK1 and ERK2 cascade cell-substrate junction assembly substrate adhesion-dependent cell spreading integrin activation positive regulation of axon extension cell-matrix adhesion leukocyte migration response to wounding extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2335 14268 Ensembl ENSG00000115414 ENSMUSG00000026193 UniProt P02751 P11276 RefSeq (mRNA) NM_001306129 NM_001306130 NM_001306131 NM_001306132 NM_002026 NM_054034 NM_212474 NM_212475 NM_212476 NM_212478 NM_212482 NM_001365517 NM_001365518 NM_001365519 NM_001365520 NM_001365521 NM_001365522 NM_001365523 NM_001365524 NM_001276408 NM_001276409 NM_001276410 NM_001276411 NM_001276412 NM_001276413 NM_010233 RefSeq (protein) NP_001293058 NP_001293059 NP_001293060 NP_001293061 NP_002017 NP_473375 NP_997639 NP_997641 NP_997643 NP_997647 NP_001352446 NP_001352447 NP_001352448 NP_001352449 NP_001352450 NP_001352451 NP_001352452 NP_001352453 NP_001293058.1 NP_001293059.1 NP_001293061.1 NP_001263337 NP_001263338 NP_001263339 NP_001263340 NP_001263341 NP_001263342 NP_034363 Location (UCSC) Chr 2: 215.36 – 215.44 Mb Chr 1: 71.62 – 71.69 Mb PubMed search [3] [4]
Wikidata
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Fibronectin is a high-molecular weight (~500-~600 kDa)^[5] glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins.^[6] Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).

Fibronectin exists as a protein dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds.^[6] The fibronectin protein is produced from a single gene, but alternative splicing of its pre-mRNA leads to the creation of several isoforms.

Two types of fibronectin are present in vertebrates:^[6]

• soluble plasma fibronectin (formerly called "cold-insoluble globulin", or CIg) is a major protein component of blood plasma (300 μg/ml) and is produced in the liver by hepatocytes.
• insoluble cellular fibronectin is a major component of the extracellular matrix. It is secreted by various cells, primarily fibroblasts, as a soluble protein dimer and is then assembled into an insoluble matrix in a complex cell-mediated process.

Fibronectin plays a major role in cell adhesion, growth, migration, and differentiation, and it is important for processes such as wound healing and embryonic development.^[6] Altered fibronectin expression, degradation, and organization has been associated with a number of pathologies, including cancer, arthritis, and fibrosis.^[7][8]