Our website is made possible by displaying online advertisements to our visitors.
Please consider supporting us by disabling your ad blocker.

Responsive image

Strategies for engineered negligible senescence

Strategies for engineered negligible senescence (SENS) is a range of proposed regenerative medical therapies, either planned or currently in development, for the periodic repair of all age-related damage to human tissue. These therapies have the ultimate aim of maintaining a state of negligible senescence in patients and postponing age-associated disease.[1] SENS was first defined by British biogerontologist Aubrey de Grey. Many mainstream scientists believe that it is a fringe theory.[2] De Grey later highlighted similarities and differences of SENS to subsequent categorization systems of the biology of aging, such as the highly influential Hallmarks of Aging published in 2013.[3][4]

While some biogerontologists support the SENS program, others contend that the ultimate goals of de Grey's programme are too speculative given the current state of technology.[5][6] The 31-member Research Advisory Board of de Grey's SENS Research Foundation have signed an endorsement of the plausibility of the SENS approach.[7]

  1. ^ de Grey, Aubrey; Rae, Michael (September 2007). Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime. New York, NY: St. Martin's Press, 416 pp. ISBN 0-312-36706-6.
  2. ^ Warner, H.; Anderson, J.; Austad, S.; Bergamini, E.; Bredesen, D.; Butler, R.; Carnes, B. A.; Clark, B. F. C.; Cristofalo, V.; Faulkner, J.; Guarente, L.; Harrison, D. E.; Kirkwood, T.; Lithgow, G.; Martin, G.; Masoro, E.; Melov, S.; Miller, R. A.; Olshansky, S. J.; Partridge, L.; Pereira-Smith, O.; Perls, T.; Richardson, A.; Smith, J.; Von Zglinicki, T.; Wang, E.; Wei, J. Y.; Williams, T. F. (Nov 2005). "Science fact and the SENS agenda. What can we reasonably expect from ageing research?". EMBO Reports. 6 (11): 1006–1008. doi:10.1038/sj.embor.7400555. ISSN 1469-221X. PMC 1371037. PMID 16264422.
  3. ^ De Grey, Aubrey D.N.J. (2023). "The Divide-and-Conquer Approach to Delaying Age-Related Functional Decline: Where Are We Now?". Rejuvenation Research. 26 (6): 217–220. doi:10.1089/rej.2023.0057. PMID 37950714. S2CID 265127778.
  4. ^ "The Hallmarks of Aging: Cell".
  5. ^ Warner H; Anderson J; Austad S; et al. (November 2005). "Science fact and the SENS agenda. What can we reasonably expect from ageing research?". EMBO Reports. 6 (11): 1006–8. doi:10.1038/sj.embor.7400555. PMC 1371037. PMID 16264422.
  6. ^ Holliday R (April 2009). "The extreme arrogance of anti-aging medicine". Biogerontology. 10 (2): 223–8. doi:10.1007/s10522-008-9170-6. PMID 18726707. S2CID 764136.
  7. ^ "Research Advisory Board". sens.org. Archived from the original on 14 June 2021. Retrieved 15 July 2021.

Previous Page Next Page






Strategies for Engineered Negligible Senescence German Strategies for engineered negligible senescence Greek Strategies for Engineered Negligible Senescence French Strategies for Engineered Negligible Senescence Portuguese Стратегии достижения пренебрежимого старения инженерными методами Russian SENS Research Foundation SQ 掌控可忽略衰老 Chinese

Responsive image

Responsive image