| 2021 Chicago White Sox | ||
|---|---|---|
| American League Central Champions | ||
 | ||
| League | American League | |
| Division | Central | |
| Ballpark | Guaranteed Rate Field | |
| City | Chicago | |
| Record | 93–69 (.574) | |
| Divisional place | 1st | |
| Owners | Jerry Reinsdorf | |
| General managers | Rick Hahn | |
| Managers | Tony La Russa | |
| Television | NBC Sports Chicago NBC Sports Chicago+ (Jason Benetti, Steve Stone, Len Kasper, Mike Monaco (fill-in), Gordon Beckham) | |
| Radio | ESPN Chicago Chicago White Sox Radio Network (Len Kasper, Darrin Jackson, Connor McKnight) WRTO-AM (Spanish) (Hector Molina, Billy Russo) | |
| Stats | ESPN.com Baseball Reference | |
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The 2021 Chicago White Sox season was the club's 122nd season in Chicago and 121st in the American League, and their first under returning manager Tony La Russa since 1986. The White Sox played their home games at Guaranteed Rate Field. On September 23, after a win against the Cleveland Indians, the White Sox clinched the American League Central for the first time since the 2008 season and became the first Major League team of the 2021 season to clinch their division. They finished the regular season with 93 wins, the third most in the American League and their most wins as a franchise since the 2005 season. By winning the American League Central, it secured the team their first back-to-back postseason appearance in franchise history after having clinched a wild card berth in the previous season. They lost to the Houston Astros in the 2021 American League Division Series. As of the 2024 MLB Season, this was the last season the White Sox qualified for the MLB postseason.