ADAMTS13

ADAMTS13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3GHM, 3GHN
Identifiers
Aliases	ADAMTS13, ADAM-TS13, ADAMTS-13, C9orf8, VWFCP, vWF-CP, ADAM metallopeptidase with thrombospondin type 1 motif 13
External IDs	OMIM: 604134; MGI: 2685556; HomoloGene: 16372; GeneCards: ADAMTS13; OMA:ADAMTS13 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,459,402 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	26,899,640 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right hemisphere of cerebellum; ; right uterine tube; ; right frontal lobe; ; right testis; ; left testis; ; primary visual cortex; ; Pituitary Gland; ; apex of heart; ; Brodmann area 9;
	Top expressed in
	liver; ; dentate gyrus of hippocampal formation granule cell; ; morula; ; bone marrow; ; embryo; ; esophagus; ; hippocampus proper; ; primary visual cortex; ; yolk sac; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; endopeptidase activity; metal ion binding; integrin binding; peptidase activity; protein binding; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; zinc ion binding;
Cellular component	endoplasmic reticulum lumen; extracellular region; cell surface; extracellular space; extracellular matrix;
Biological process	hemostasis; glycoprotein metabolic process; response to interleukin-4; response to interferon-gamma; protein processing; blood coagulation; proteolysis; platelet activation; response to tumor necrosis factor; integrin-mediated signaling pathway; cell-matrix adhesion; response to toxic substance; peptide catabolic process; response to potassium ion; cellular response to interferon-gamma; cellular response to lipopolysaccharide; response to amine; cellular response to interleukin-4; cellular response to tumor necrosis factor;
	Sources:Amigo / QuickGO
Orthologs
	11093
	279028
	ENSG00000160323; ENSG00000281244
	ENSMUSG00000014852
	Q76LX8
	Q769J6
	NM_139025; NM_139026; NM_139027; NM_139028
	NM_001001322; NM_001290463; NM_001290464; NM_001290465
	NP_620594; NP_620595; NP_620596
	NP_001001322; NP_001277392; NP_001277393; NP_001277394
	Wikidata
View/Edit Human	View/Edit Mouse

ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting. It is secreted into the blood and degrades large vWf multimers, decreasing their activity, hence ADAMTS13 acts to reduce thrombus formation.^[5]

^ ^a ^b ^c ENSG00000281244 GRCh38: Ensembl release 89: ENSG00000160323, ENSG00000281244 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014852 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Levy GG, Motto DG, Ginsburg D (July 2005). "ADAMTS13 turns 3". Blood. 106 (1): 11–7. doi:10.1182/blood-2004-10-4097. PMID 15774620. S2CID 25645477.

[refGRCh38Ensembl-1] ENSG00000281244 GRCh38: Ensembl release 89: ENSG00000160323, ENSG00000281244 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014852 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Levy2005-5] Levy GG, Motto DG, Ginsburg D (July 2005). "ADAMTS13 turns 3". Blood. 106 (1): 11–7. doi:10.1182/blood-2004-10-4097. PMID 15774620. S2CID 25645477.

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