Alcmene may refer to:
- Alcmene, mother of Heracles in Greek mythology
- 82 Alkmene, the asteroid
- Alkmene (apple)
- Alkmene (opera), the opera by Giselher Klebe
- HMS Alcmene, one of several ships of the British Royal Navy
- French frigate Alcmène (1774)
- French frigate Alcmène (1811)