Apolipoprotein C-I

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ApoC-I
ApoC-I
	structural studies of a baboon (papio sp.) plasma protein inhibitor of cholesteryl ester transferase.
Identifiers
Symbol	ApoC-I
Pfam	PF04691
InterPro	IPR006781
SCOP2	1ale / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

APOC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ALE, 1ALF, 1IOJ, 1OPP
Identifiers
Aliases	APOC1, Apo-CI, ApoC-I, apo-CIB, apoC-IB, apolipoprotein C1, Apolipoprotein C-I
External IDs	OMIM: 107710; MGI: 88053; HomoloGene: 136749; GeneCards: APOC1; OMA:APOC1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,919,349 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,426,585 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; left adrenal cortex; ; right adrenal cortex; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; right lung; ; spleen; ; substantia nigra; ; Hypothalamus;
	Top expressed in
	left lobe of liver; ; gallbladder; ; lip; ; blastocyst; ; brown adipose tissue; ; skin of external ear; ; yolk sac; ; transitional epithelium of urinary bladder; ; esophagus; ; tunica adventitia of aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding; phosphatidylcholine-sterol O-acyltransferase activator activity;
Cellular component	chylomicron; very-low-density lipoprotein particle; endoplasmic reticulum; high-density lipoprotein particle; extracellular region;
Biological process	lipid transport; chylomicron remnant clearance; negative regulation of fatty acid biosynthetic process; lipid metabolism; positive regulation of cholesterol esterification; phospholipid efflux; cholesterol metabolic process; negative regulation of phosphatidylcholine catabolic process; plasma lipoprotein particle remodeling; negative regulation of very-low-density lipoprotein particle clearance; regulation of cholesterol transport; negative regulation of receptor-mediated endocytosis; high-density lipoprotein particle remodeling; cholesterol efflux; negative regulation of cholesterol transport; negative regulation of lipoprotein lipase activity; very-low-density lipoprotein particle assembly; negative regulation of lipid catabolic process; triglyceride metabolic process; negative regulation of lipid metabolic process; positive regulation of catalytic activity; very-low-density lipoprotein particle clearance; lipoprotein metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	341
	11812
	ENSG00000130208
	ENSMUSG00000040564
	P02654
	P34928
	NM_001645; NM_001321065; NM_001321066; NM_001379687
	NM_001110009; NM_007469
	NP_001307994; NP_001307995; NP_001636; NP_001366616
	NP_001103479; NP_031495
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein C-I is a protein component of lipoproteins that in humans is encoded by the APOC1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130208 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040564 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tata F, Henry I, Markham AF, Wallis SC, Weil D, Grzeschik KH, et al. (1985). "Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19". Human Genetics. 69 (4): 345–9. doi:10.1007/BF00291654. PMID 2985493. S2CID 32767041.
^ Smit M, van der Kooij-Meijs E, Frants RR, Havekes L, Klasen EC (January 1988). "Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia". Human Genetics. 78 (1): 90–3. doi:10.1007/BF00291243. PMID 2892779. S2CID 22711986.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130208 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040564 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2985493-5] Tata F, Henry I, Markham AF, Wallis SC, Weil D, Grzeschik KH, et al. (1985). "Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19". Human Genetics. 69 (4): 345–9. doi:10.1007/BF00291654. PMID 2985493. S2CID 32767041.

[pmid2892779-6] Smit M, van der Kooij-Meijs E, Frants RR, Havekes L, Klasen EC (January 1988). "Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia". Human Genetics. 78 (1): 90–3. doi:10.1007/BF00291243. PMID 2892779. S2CID 22711986.

[1]

[2]

[3]

[4]

[5]

[6]