CYP1A2

CYP1A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HI4
Identifiers
Aliases	CYP1A2, CP12, P3-450, P450(PA), cytochrome P450 family 1 subfamily A member 2, Cytochrome P450 1A2, CYPIA2
External IDs	OMIM: 124060; MGI: 88589; HomoloGene: 68082; GeneCards: CYP1A2; OMA:CYP1A2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.1 Start 74,748,845 bp[1] End 74,756,607 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 B|9 31.3 cM Start 57,584,220 bp[2] End 57,590,986 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell right lobe of liver superficial temporal artery cardia nipple vena cava mucosa of paranasal sinus subthalamic nucleus sperm ventral tegmental area Top expressed in left lobe of liver olfactory epithelium gallbladder sexually immature organism duodenum thoracic diaphragm medial head of gastrocnemius muscle right lung lobe thymus pancreas More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding demethylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen metal ion binding caffeine oxidase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enzyme binding oxidoreductase activity aromatase activity electron transfer activity monooxygenase activity Cellular component organelle membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle membrane endoplasmic reticulum Biological process response to immobilization stress toxin metabolic process steroid metabolic process response to estradiol alkaloid metabolic process response to organic cyclic compound lung development lipid metabolism epoxygenase P450 pathway cellular response to cadmium ion post-embryonic development monocarboxylic acid metabolic process response to organic substance oxidative demethylation response to lipopolysaccharide methylation steroid catabolic process omega-hydroxylase P450 pathway dibenzo-p-dioxin metabolic process heterocycle metabolic process cellular respiration cellular aromatic compound metabolic process regulation of gene expression hydrogen peroxide biosynthetic process monoterpenoid metabolic process xenobiotic metabolic process porphyrin-containing compound metabolic process toxin biosynthetic process cellular response to copper ion electron transport chain long-chain fatty acid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1544 13077 Ensembl ENSG00000140505 ENSMUSG00000032310 UniProt P05177 P00186 RefSeq (mRNA) NM_000761 NM_009993 RefSeq (protein) NP_000752 NP_034123 Location (UCSC) Chr 15: 74.75 – 74.76 Mb Chr 9: 57.58 – 57.59 Mb PubMed search [3] [4]
Wikidata
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Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body.^[5] In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene.^[6]