CYP3A43

CYP3A43
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1TQN, 1W0E, 1W0F, 1W0G, 2J0D, 2V0M, 3NXU, 3TJS, 3UA1, 4I3Q, 4I4G, 4I4H, 4K9T, 4K9U, 4K9V, 4K9W, 4K9X, 4NY4, 5A1P, 5A1R
Identifiers
Aliases	CYP3A43, cytochrome P450 family 3 subfamily A member 43
External IDs	OMIM: 606534; HomoloGene: 136124; GeneCards: CYP3A43; OMA:CYP3A43 - orthologs
EC number	1.14.14.56
Gene location (Human)
Chr.	Chromosome 7 (human)
End	99,866,093 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; testicle; ; mucosa of ileum; ; body of pancreas; ; jejunal mucosa; ; sperm; ; skeletal muscle tissue; ; lower limb muscles; ; prostate;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Orthologs
	64816
	n/a
	ENSG00000021461
	n/a
	Q9HB55
	n/a
	NM_001278921; NM_022820; NM_057095; NM_057096
	n/a
	NP_001265850; NP_073731; NP_476436; NP_476437
	n/a
	Wikidata
View/Edit Human

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.^[3]^[4]^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000021461 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG (Feb 2001). "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450". Mol Pharmacol. 59 (2): 386–92. doi:10.1124/mol.59.2.386. PMID 11160876.
^ Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L (Mar 2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene". Pharmacogenetics. 11 (2): 111–21. doi:10.1097/00008571-200103000-00002. PMID 11266076.
^ ^a ^b "Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000021461 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11160876-3] Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG (Feb 2001). "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450". Mol Pharmacol. 59 (2): 386–92. doi:10.1124/mol.59.2.386. PMID 11160876.

[pmid11266076-4] Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L (Mar 2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene". Pharmacogenetics. 11 (2): 111–21. doi:10.1097/00008571-200103000-00002. PMID 11266076.

[entrez-5] "Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43".

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