Carboxylesterase 1

CES1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MX1, 1MX5, 1MX9, 1YA4, 1YA8, 1YAH, 1YAJ, 2DQY, 2DQZ, 2DR0, 2H7C, 2HRQ, 2HRR, 3K9B, 4AB1, 5A7F, 5A7H, 5A7G
Identifiers
Aliases	CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1, carboxylesterase 1
External IDs	OMIM: 114835; MGI: 2148202; HomoloGene: 35606; GeneCards: CES1; OMA:CES1 - orthologs
EC number	3.1.1.1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	55,833,337 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	93,924,466 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gallbladder; ; right lung; ; olfactory zone of nasal mucosa; ; upper lobe of left lung; ; smooth muscle tissue; ; apex of heart; ; muscle layer of sigmoid colon; ; Descending thoracic aorta; ; epithelium of colon;
	Top expressed in
	white adipose tissue; ; lacrimal gland; ; gallbladder; ; right lung lobe; ; nasal epithelium; ; tunica adventitia of aorta; ; olfactory epithelium; ; superior surface of tongue; ; brown adipose tissue; ; left lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	methylumbelliferyl-acetate deacetylase activity; carboxylic ester hydrolase activity; hydrolase activity; sterol esterase activity; triglyceride lipase activity; methyl indole-3-acetate esterase activity;
Cellular component	endoplasmic reticulum lumen; cytosol; endoplasmic reticulum; extracellular space;
Biological process	xenobiotic metabolic process; epithelial cell differentiation; response to toxic substance; cholesterol ester hydrolysis involved in cholesterol transport; cholesterol biosynthetic process; medium-chain fatty acid metabolic process; lipid catabolic process; angiotensin maturation;
	Sources:Amigo / QuickGO
Orthologs
	1066
	104158
	ENSG00000198848; ENSG00000262243
	ENSMUSG00000056973
	P23141
	Q8VCT4
	NM_001025194; NM_001025195; NM_001266
	NM_053200
	NP_001020365; NP_001020366; NP_001257
	NP_444430
	Wikidata
View/Edit Human	View/Edit Mouse

Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the CES1 gene.^[5]^[6] The protein is also historically known as serine esterase 1 (SES1), monocyte esterase and cholesterol ester hydrolase (CEH). Three transcript variants encoding three different isoforms have been found for this gene.^[6] The various protein products from isoform a, b and c range in size from 568, 567 and 566 amino acids long, respectively.

CES1 is present in most tissues with higher levels in the liver and low levels in the gastrointestinal tract.^[7]

^ ^a ^b ^c ENSG00000262243 GRCh38: Ensembl release 89: ENSG00000198848, ENSG00000262243 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056973 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zschunke F, Salmassi A, Kreipe H, Buck F, Parwaresch MR, Radzun HJ (Aug 1991). "cDNA cloning and characterization of human monocyte/macrophage serine esterase-1". Blood. 78 (2): 506–12. doi:10.1182/blood.V78.2.506.506. PMID 2070086.
^ ^a ^b "Entrez Gene: CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1)".
^ Imai T (Jun 2006). "Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120.

[refGRCh38Ensembl-1] ENSG00000262243 GRCh38: Ensembl release 89: ENSG00000198848, ENSG00000262243 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056973 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2070086-5] Zschunke F, Salmassi A, Kreipe H, Buck F, Parwaresch MR, Radzun HJ (Aug 1991). "cDNA cloning and characterization of human monocyte/macrophage serine esterase-1". Blood. 78 (2): 506–12. doi:10.1182/blood.V78.2.506.506. PMID 2070086.

[entrez-6] "Entrez Gene: CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1)".

[pmid16858120-7] Imai T (Jun 2006). "Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120.

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