Dexamethasone suppression test

Dexamethasone suppression test
Purposeassess adrenal gland function
proopiomelanocortin derivatives
POMC
     
γ-MSH ACTH β-lipotropin
         
  α-MSH CLIP γ-lipotropin β-endorphin
       
    β-MSH  

The dexamethasone suppression test (DST) is used to assess adrenal gland function by measuring how cortisol levels change in response to oral doses or an injection of dexamethasone.[1] It is typically used to diagnose Cushing's syndrome.

The DST was historically used for diagnosing depression, but by 1988 it was considered to be "at best, severely limited in its clinical ability" for this purpose.[2]

  1. ^ Dogra, Prerna; Vijayashankar, Narasimha P. (2020). "Dexamethasone Suppression Test". StatPearls. StatPearls Publishing. PMID 31194457. Retrieved 26 December 2020.
  2. ^ Nierenberg AA, Feinstein AR (1988). "How to evaluate a diagnostic marker test. Lessons from the rise and fall of dexamethasone suppression test". JAMA. 259 (11): 1699–702. doi:10.1001/jama.1988.03720110061036. PMID 3278149.

Dexamethasone suppression test

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