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The discovery of cells and the cell cycle is critical to our modern understanding of living systems, and the fields of biology, biochemistry, biophysics, and medicine, as well as many others. While Robert Hooke initially discovered cells in 1665, research in the cell cycle has made most of its notable progress in the last two centuries. This includes the first descriptions of mitotic progression, the description of the entire cell cycle including the different parts of interphase, a new molecular understanding of the drivers of the cell cycle, and the discovery of the essential checkpoints.