Francisco Tenamaztle (fl. 1540s–1550s), also Tenamaxtlan, Tenamaxtli or Tenamaxtle, was a leader of the Caxcan Indigenous peoples in Mexico during the Mixtón War of 1540–1542.[1] He was later put on trial in Spain. With the support of Bartolomé de las Casas he defended the justice of his cause by appealing to King Carlos I.