ICBM refers to an intercontinental ballistic missile.
ICBM may also refer to:
- Institute for Chemistry and Biology of the Marine Environment, Lower Saxony, Germany
- I.C.B.M. (board game)
- International Consortium for Brain Mapping; terms such as ICBM152, ICBM452 refer to brain atlases
- ICBM, a 2020 computer game by Slitherine
- Tennison Gambit, A chess opening also known as the ICBM gambit.