Industrial fermentation

Industrial fermentation is the intentional use of fermentation in manufacturing processes. In addition to the mass production of fermented foods and drinks, industrial fermentation has widespread applications in chemical industry. Commodity chemicals, such as acetic acid, citric acid, and ethanol are made by fermentation.^[1] Moreover, nearly all commercially produced industrial enzymes, such as lipase, invertase and rennet, are made by fermentation with genetically modified microbes. In some cases, production of biomass itself is the objective, as is the case for single-cell proteins, baker's yeast, and starter cultures for lactic acid bacteria used in cheesemaking.

In general, fermentations can be divided into four types:^[2]

Production of biomass (viable cellular material)
Production of extracellular metabolites (chemical compounds)
Production of intracellular components (enzymes and other proteins)
Transformation of substrate (in which the transformed substrate is itself the product)

These types are not necessarily disjoined from each other, but provide a framework for understanding the differences in approach. The organisms used are typically microorganisms, particularly bacteria, algae, and fungi, such as yeasts and molds, but industrial fermentation may also involve cell cultures from plants and animals, such as CHO cells and insect cells. Special considerations are required for the specific organisms used in the fermentation, such as the dissolved oxygen level, nutrient levels, and temperature. The rate of fermentation depends on the concentration of microorganisms, cells, cellular components, and enzymes as well as temperature, pH^[3] and level of oxygen for aerobic fermentation.^[4] Product recovery frequently involves the concentration of the dilute solution.

^ Yusuf C (1999). Robinson RK (ed.). Encyclopedia of Food Microbiology (PDF). London: Academic Press. pp. 663–674. ISBN 978-0-12-227070-3. Archived from the original (PDF) on 2016-03-07. Retrieved 2014-04-09.
^ Stanbury PF, Whiitaker A, Hall SJ (1999). Principles of Fermentation Technology (Second ed.). Butterworth-Heinemann. ISBN 978-0750645010.
^ "Fermentation". Rpi.edu. Archived from the original on 2015-06-15. Retrieved 2015-06-02.
^ Rao DG (2010). Introduction to Biochemical Engineering – Dubasi Govardhana Rao. Tata McGraw-Hill. ISBN 9780070151383. Retrieved 2015-06-02.

[1] Yusuf C (1999). Robinson RK (ed.). Encyclopedia of Food Microbiology (PDF). London: Academic Press. pp. 663–674. ISBN 978-0-12-227070-3. Archived from the original (PDF) on 2016-03-07. Retrieved 2014-04-09.

[2] Stanbury PF, Whiitaker A, Hall SJ (1999). Principles of Fermentation Technology (Second ed.). Butterworth-Heinemann. ISBN 978-0750645010.

[Fermentation-3] "Fermentation". Rpi.edu. Archived from the original on 2015-06-15. Retrieved 2015-06-02.

[4] Rao DG (2010). Introduction to Biochemical Engineering – Dubasi Govardhana Rao. Tata McGraw-Hill. ISBN 9780070151383. Retrieved 2015-06-02.

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