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Middle East empires have existed in the Middle East region at various periods between 3000 BCE and 1924 CE; they have been instrumental in the spreading of ideas, technology, and religions within Middle East territories and to outlying territories. Since the 7th century CE, all Middle East empires, with the exception of the Byzantine Empire, were Islamic and some of them claiming the titles of an Islamic caliphate. The last major empire based in the region was the Ottoman Empire.