OPN1LW

OPN1LW
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KPX
Identifiers
Aliases	OPN1LW, CBBM, CBP, COD5, RCP, ROP, opsin 1 (cone pigments), long-wave-sensitive, opsin 1, long wave sensitive
External IDs	OMIM: 300822; MGI: 1097692; HomoloGene: 68064; GeneCards: OPN1LW; OMA:OPN1LW - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	154,159,032 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,194,366 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; blood; ; left uterine tube; ; skin of leg; ; left adrenal cortex; ; lobe of thyroid gland; ; left lobe of thyroid gland; ; ascending aorta; ; right ovary; ; prostate;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; retinal pigment epithelium; ; epithelium of lens; ; embryo; ; outer nuclear layer; ; knee joint; ; soleus muscle; ; skeletal muscle tissue; ; quadriceps femoris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; photoreceptor activity; signal transducer activity; G protein-coupled photoreceptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; photoreceptor outer segment; photoreceptor disc membrane;
Biological process	positive regulation of cytokinesis; signal transduction; visual perception; retinoid metabolic process; response to stimulus; phototransduction; detection of visible light; G protein-coupled receptor signaling pathway; cellular response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5956
	14539
	ENSG00000102076
	ENSMUSG00000031394
	P04000
	O35599
	NM_020061
	NM_008106
	NP_064445
	NP_032132
	Wikidata
View/Edit Human	View/Edit Mouse

OPN1LW is a gene on the X chromosome that encodes for long wave sensitive (LWS) opsin, or red cone photopigment.^[5] It is responsible for perception of visible light in the yellow-green range on the visible spectrum (around 500-570nm).^[6]^[7] The gene contains 6 exons with variability that induces shifts in the spectral range.^[8] OPN1LW is subject to homologous recombination with OPN1MW, as the two have very similar sequences.^[8] These recombinations can lead to various vision problems, such as red-green colourblindness and blue monochromacy.^[9] The protein encoded is a G-protein coupled receptor with embedded 11-cis-retinal, whose light excitation causes a cis-trans conformational change that begins the process of chemical signalling to the brain.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102076 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031394 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference NCBI was invoked but never defined (see the help page).
^ Cite error: The named reference Hofmann_2015 was invoked but never defined (see the help page).
^ Cite error: The named reference Merbs_1992 was invoked but never defined (see the help page).
^ ^a ^b Cite error: The named reference Neitz_2011 was invoked but never defined (see the help page).
^ Cite error: The named reference Genetics Home Reference was invoked but never defined (see the help page).
^ Cite error: The named reference Imamoto_2014 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102076 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031394 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[NCBI-5] Cite error: The named reference NCBI was invoked but never defined (see the help page).

[Hofmann_2015-6] Cite error: The named reference Hofmann_2015 was invoked but never defined (see the help page).

[Merbs_1992-7] Cite error: The named reference Merbs_1992 was invoked but never defined (see the help page).

[Neitz_2011-8] Cite error: The named reference Neitz_2011 was invoked but never defined (see the help page).

[Genetics_Home_Reference-9] Cite error: The named reference Genetics Home Reference was invoked but never defined (see the help page).

[Imamoto_2014-10] Cite error: The named reference Imamoto_2014 was invoked but never defined (see the help page).

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