Back Pegvisomant German Pegvisomante Spanish Pegvisomant French Pegvisomant Italian ペグビソマント Japanese Пегвисомант MK ପେଗଭିସୋମାଣ୍ଟ OR Pegwisomant Polish Pegvisomanto Portuguese Pegvisomant SH
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| Trade names | Somavert |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | Subcutaneous |
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| Formula | C990H1532N262O300S7 |
| Molar mass | 22129.10 g·mol−1 |
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Pegvisomant, sold under the brand name Somavert, is a growth hormone receptor antagonist used in the treatment of acromegaly.[1][2][3] It is primarily used if the pituitary gland tumor causing the acromegaly cannot be controlled with surgery or radiation, and the use of somatostatin analogues is unsuccessful, but is also effective as a monotherapy.[4] It is delivered as a powder that is mixed with water and injected under the skin.[5]
- ^ a b "Somavert- pegvisomant kit". DailyMed. 18 November 2021. Retrieved 18 May 2022.
- ^ a b "Somavert EPAR". European Medicines Agency. 17 September 2018. Retrieved 18 May 2022.
- ^ Schreiber I, Buchfelder M, Droste M, Forssmann K, Mann K, Saller B, Strasburger CJ (January 2007). "Treatment of acromegaly with the GH receptor antagonist pegvisomant in clinical practice: safety and efficacy evaluation from the German Pegvisomant Observational Study". European Journal of Endocrinology. 156 (1): 75–82. doi:10.1530/eje.1.02312. PMID 17218728. S2CID 12121175.
- ^ Freda PU, Gordon MB, Kelepouris N, Jonsson P, Koltowska-Haggstrom M, van der Lely AJ (March 2015). "Long-term treatment with pegvisomant as monotherapy in patients with acromegaly: experience from ACROSTUDY". Endocrine Practice. 21 (3): 264–74. doi:10.4158/EP14330.OR. PMC 4618502. PMID 25370326.
- ^ Scientific Discussion of Somavert (PDF) (Report). European Medicines Agency. 2004. Archived from the original (PDF) on 18 June 2018. Retrieved 17 February 2011.