Back بوليميراز الرنا المعتمدة على الرنا Arabic RNK-ovisna RNK-polimeraza BS RNA-abhängige RNA-Polymerase German ARN polimerasa dependiente de ARN Spanish آرانای پلیمراز وابسته به آرانای FA RNA-replikaasi Finnish ARN polymérase ARN-dépendante French RNA רפליקאז HE RNA依存性RNAポリメラーゼ Japanese RNA 의존적 RNA 중합효소 Korean
| RNA-dependent RNA polymerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Stalled HCV RNA replicase (NS5B), in complex with sofosbuvir (PDB 4WTG). | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.7.48 | ||||||||
| CAS no. | 9026-28-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template. This is in contrast to typical DNA-dependent RNA polymerases, which all organisms use to catalyze the transcription of RNA from a DNA template.
RdRp is an essential protein encoded in the genomes of most RNA-containing viruses that lack a DNA stage,[1][2] including SARS-CoV-2. Some eukaryotes also contain RdRps, which are involved in RNA interference and differ structurally from viral RdRps.
- ^ Koonin EV, Gorbalenya AE, Chumakov KM (July 1989). "Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relationship to positive strand RNA viral polymerases". FEBS Letters. 252 (1–2): 42–46. Bibcode:1989FEBSL.252...42K. doi:10.1016/0014-5793(89)80886-5. PMID 2759231. S2CID 36482110.
- ^ Zanotto PM, Gibbs MJ, Gould EA, Holmes EC (September 1996). "A reevaluation of the higher taxonomy of viruses based on RNA polymerases". Journal of Virology. 70 (9): 6083–6096. doi:10.1128/JVI.70.9.6083-6096.1996. PMC 190630. PMID 8709232.