Smythe, a less common spelling of the surname Smith, may refer to:
- Conn Smythe (1895–1980), Canadian businessman, soldier and sportsman in ice hockey and horse racing
- Dallas Smythe (1907–1992), Canadian political activist and researcher
- Danny Smythe (1948–2016), American drummer, member of the rock band The Box Tops
- Douglas Smythe, American visual effects artist, see Academy Award for Best Visual Effects
- Durham Smythe (born 1995), American football player
- Faye Smythe (born 1985), New Zealand actress
- Frank Smythe (1900–1949), British mountaineer, author, photographer, and botanist
- George Smythe, 7th Viscount Strangford (1818–1857), British politician
- James Moore Smythe (1702–1734), English playwright and fop
- John Smythe (disambiguation) several persons of this name
- Liz Smythe, New Zealand nursing and midwifery professor
- Pat Smythe (pianist) (1923–1983), Scottish jazz pianist
- Pat Smythe (1928–1996), British show jumper
- Percy Smythe, 6th Viscount Strangford (1780–1855), British diplomat
- Percy Smythe, 8th Viscount Strangford (1826–1869), British man of letters
- Peter Smythe (disambiguation) several persons of this name
- Philip Smythe, 2nd Viscount Strangford (1634–1708), English politician
- Quentin Smythe (1916–1997), South African World War II recipient of the Victoria Cross
- Reg Smythe (1917–1998), British cartoonist
- Stafford Smythe (1921–1971), Canadian ice hockey player and manager
- Thomas Smythe (c.1558–1625), English merchant and politician
- Thomas Smythe, 1st Viscount Strangford (1599–1635)
- William Smythe (disambiguation) several persons of this name