Tincture of iodine

Iodine tincture
	Various bottles of tincture of iodine from the former Soviet Union
Clinical data
AHFS/Drugs.com	Monograph
Pregnancy; category	D;
Routes of; administration	Topical
ATCvet code	QD08AG (WHO) ;
Identifiers
	IUPAC name diiodane;
CAS Number	7553-56-2;
PubChem CID	807;
DrugBank	DB05382;
UNII	9679TC07X4;
Chemical and physical data
Formula	I2

Tincture of iodine, iodine tincture, or weak iodine solution is an antiseptic. It is usually 2 to 3% elemental iodine, along with potassium iodide or sodium iodide, dissolved in a mixture of ethanol and water. Tincture solutions are characterized by the presence of alcohol. It was used from 1908 in pre-operative skin preparation by Italian surgeon Antonio Grossich.^[1]^[2]

In the United Kingdom, the development of an iodine solution for skin sterilisation was pioneered by Lionel Stretton. The British Medical Journal published the detail of his work at Kidderminster Infirmary in 1909.^[3] Stretton used a much weaker solution than that used by Grossich. He claimed in 1915 that Grossich had been using a liquid akin to Liquor Iodi Fortis, and that it was he, Stretton, who had introduced the method using Tincture of Iodine BP which came to be used across the world. ^[4]

^ Cite error: The named reference Block2001 was invoked but never defined (see the help page).
^ Barenfanger J, Drake C, Lawhorn J, Verhulst SJ (May 2004). "Comparison of chlorhexidine and tincture of iodine for skin antisepsis in preparation for blood sample collection". Journal of Clinical Microbiology. 42 (5): 2216–2217. doi:10.1128/JCM.42.5.2216-2217.2004. PMC 404630. PMID 15131193.
^ Stretton JL (August 1909). "The Sterilization of the Skin of Operation Areas". British Medical Journal. 2 (2537): 368–369. doi:10.1136/bmj.2.2537.368-a. PMC 2320536. PMID 20764617.
^ Stretton JL (May 1915). "The Sterilisation of the Skin with Tincture of Iodine". British Medical Journal. 1 (2838): 886–887. doi:10.1136/bmj.1.2838.886. PMC 2302255. PMID 20767647.

[Block2001-1] Cite error: The named reference Block2001 was invoked but never defined (see the help page).

[2] Barenfanger J, Drake C, Lawhorn J, Verhulst SJ (May 2004). "Comparison of chlorhexidine and tincture of iodine for skin antisepsis in preparation for blood sample collection". Journal of Clinical Microbiology. 42 (5): 2216–2217. doi:10.1128/JCM.42.5.2216-2217.2004. PMC 404630. PMID 15131193.

[3] Stretton JL (August 1909). "The Sterilization of the Skin of Operation Areas". British Medical Journal. 2 (2537): 368–369. doi:10.1136/bmj.2.2537.368-a. PMC 2320536. PMID 20764617.

[4] Stretton JL (May 1915). "The Sterilisation of the Skin with Tincture of Iodine". British Medical Journal. 1 (2838): 886–887. doi:10.1136/bmj.1.2838.886. PMC 2302255. PMID 20767647.

[1]

[2]

[3]

[4]