Vitamin K-dependent protein

A Vitamin K-dependent protein (VKDP) is a protein that can bind calcium ions but only after being carboxylated at a certain glutamic residue. This carboxylation, said to activate the protein, is facilitated by some form of vitamin K₁ or vitamin K₂. The relevant part of a vitamin K-dependent protein is a Gla domain, and such a protein is informally called a Gla protein.^[1] Some Gla proteins have "Gla" in their name, for example Matrix Gla protein,^[1] but many don't, such as osteocalcin.^[2]

^ ^a ^b Berkner, Kathleen L.; Runge, Kurt W. (2022-05-20). "Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease". International Journal of Molecular Sciences. 23 (10). MDPI AG: 5759. doi:10.3390/ijms23105759. ISSN 1422-0067. PMC 9146348.
^ Hao, Zhenyu; Jin, Da-Yun; Stafford, Darrel W.; Tie, Jian-Ke (2019-10-17). "Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study". Haematologica. 105 (8). Ferrata Storti Foundation (Haematologica): 2164–2173. doi:10.3324/haematol.2019.229047. ISSN 0390-6078. PMC 7395276.

[p265-1] Berkner, Kathleen L.; Runge, Kurt W. (2022-05-20). "Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease". International Journal of Molecular Sciences. 23 (10). MDPI AG: 5759. doi:10.3390/ijms23105759. ISSN 1422-0067. PMC 9146348.

[q733-2] Hao, Zhenyu; Jin, Da-Yun; Stafford, Darrel W.; Tie, Jian-Ke (2019-10-17). "Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study". Haematologica. 105 (8). Ferrata Storti Foundation (Haematologica): 2164–2173. doi:10.3324/haematol.2019.229047. ISSN 0390-6078. PMC 7395276.

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