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Userboxitis can be a very serious disease in which the afflicted user's number of userboxes swells beyond any purpose and can become a burden. Userboxitis is often caused by userbox addiction.
Some researchers have argued that the current nomenclature is inaccurate since the suffix "-itis" typically denotes inflammation. They proposed the alternative term "Userboxoma". This is derived from the Greek "oma" meaning "tumor" or "swelling", which draws parallels with benign tumors.