Hlorpromazin

Hlorpromazin
(IUPAC) ime
	3-(2-hloro-10H-fenotiazin-10-il)-N,N-dimetil-propan-1-amin
Klinički podaci
Identifikatori
CAS broj	50-53-3 (slobodna baza); 69-09-0 (hidrohlorid)
ATC kod	N05AA01
PubChem	2726
DrugBank	DB00477
ChemSpider	2625
UNII	U42B7VYA4P
KEGG	D00270
ChEMBL	CHEMBL71
Hemijski podaci
Formula	C17H19ClN2S
Mol. masa	318.86 g/mol (slobodna baza); 355.33 g/mol (hidrohlorid)
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3 ; Key: ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	Oralno, 30 do 50% (inter-individualne varijacije 10–70%)
Metabolizam	Hepatički, uglavnom CYP2D6
Poluvreme eliminacije	16 do 30 časa. U dugotrajnim tretmanima, CPZ indukuje svoj sopstveni metabolizam
Izlučivanje	Bilijarno i renalno, kao metaboliti (samo tragovi nepromenjenog leka)
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno, rektalno, IM, IV infuzija

Hlorpromazin (largaktil, torazin, CPZ) je lek koji pripada grupi lekova koji se nazivaju fenotiazinski antipsihotici.^[7]^[8]^[9] Spada u blaže tipične antipsihotike.^[8] Poseduje brojna farmakolološka dejstva, ali pre svega deluje na psihičke funkcije izazivajući sedaciju, odnosno smirenje.^[7] Mehanizam delovanja hlorpromazina ostvaruje se blokadom dopaminskih (D₁, D₂^[8]) i noradrenalinskih,^[8] a u manjoj meri i muskarinskih receptora.^[8] Sedativno delovanje je posledica antagonističkog delovanja na H₁-histaminske receptore.^[8]^[10]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Katritzky A.R., Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry. Academic Press. ISBN 0080429882.
↑ ^7,0 ^7,1 Galenika str. 1, Pristupljeno 29. 4. 2013.
↑ ^8,0 ^8,1 ^8,2 ^8,3 ^8,4 ^8,5 antipsihotici - Stetoskop, Pristupljeno 29. 4. 2013.
↑ Healy David (2004). The Creation of Psychopharmacology. Harvard University Press. str. 37–73. ISBN 978-0-674-01599-9. Pristupljeno 6. 7. 2010.
↑ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Katritzky2nd-6] Katritzky A.R., Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry. Academic Press. ISBN 0080429882.

[gal._s1-7] 7,0 ^7,1 Galenika str. 1, Pristupljeno 29. 4. 2013.

[stet.-8] 8,0 ^8,1 ^8,2 ^8,3 ^8,4 ^8,5 antipsihotici - Stetoskop, Pristupljeno 29. 4. 2013.

[healy1-9] Healy David (2004). The Creation of Psychopharmacology. Harvard University Press. str. 37–73. ISBN 978-0-674-01599-9. Pristupljeno 6. 7. 2010.

[GoodmanGilman-10] Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3.

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