Ksantin

Ksantin
	3,7-Dihydropurine-2,6-dione
Drugi nazivi	1H-Purin-2,6-diol
Identifikacija
CAS registarski broj	69-89-6
PubChem	1188
ChemSpider	1151
UNII	1AVZ07U9S7
DrugBank	DB02134
KEGG	C00385
ChEBI	17712
ChEMBL	CHEMBL1424
Jmol-3D slike	Slika 1
SMILES
	c1[nH]c2c(n1)nc(nc2O)O
InChI
	InChI=1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11) ; Kod: LRFVTYWOQMYALW-UHFFFAOYSA-N InChI=1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11) InChI=1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11); Kod: LRFVTYWOQMYALW-UHFFFAOYSA-N
Svojstva
Molekulska formula	C5H4N4O2
Molarna masa	152,11 g/mol
Agregatno stanje	beli prah
Tačka topljenja	razlaže se
Rastvorljivost u vodi	1 g/ 14,5 L @ 16 °C; 1 g/1,4 L @ 100 °C
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Ne treba izjednačavati sa Ksanten.

Ksantin (ksantinska kiselina, 3,7-dihidro-purin-2,6-dion) je purinska baza koja se nalazi u većini ljudskih tkiva i fluida kao i u drugim organizmima. Brojni stimulansi su izvedeni iz ksantina, npr. kofein i teobromin.^[6]

Ksantin je proizvod na putu purinske degradacije.

On se formira iz guanina posredstvom guaninske deaminaze.
On se formira iz hipoksantina posredstvom ksantinske oksidoreduktaze.
On se takođe formira iz ksantozina posredstvom purinske nukleozidne fosforilaze (PNP)^[7].

Ksantin se naknadno konvertuje u uričnu kiselinu dejstvom ksantiske oksidaze.

Avgusta 2011, objavljen je izveštaj baziran na NASA ispitivanjima meteorita nađenih na Zemlji koji sugeriše da je ksantin i srodni organski molekuli, među kojima su komponente DNK i RNK: adenin i guanin, možda mogu da budi formirani ektraterestrijalno u svemiru.^[8]^[9]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Spiller, Gene A. (1998). Caffeine. Boca Raton: CRC Press. ISBN 0-8493-2647-8.
↑ Voet, Donald; Voet, Judith; Pratt, Charlotte (2008). "The Major Pathways of Purine Catabolism in Animals," Fundamentals of Biochemistry: Life at the Molecular Level, pp. 840.
↑ Steigerwald, John (8. 8. 2011.). „NASA Researchers: DNA Building Blocks Can Be Made in Space”. NASA. Arhivirano iz originala na datum 2020-05-11. Pristupljeno 10. 8. 2011.
↑ ScienceDaily Staff (9. 8. 2011.). „DNA Building Blocks Can Be Made in Space, NASA Evidence Suggests”. ScienceDaily. Pristupljeno 9. 8. 2011.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[isbn0-8493-2647-8-6] Spiller, Gene A. (1998). Caffeine. Boca Raton: CRC Press. ISBN 0-8493-2647-8.

[7] Voet, Donald; Voet, Judith; Pratt, Charlotte (2008). "The Major Pathways of Purine Catabolism in Animals," Fundamentals of Biochemistry: Life at the Molecular Level, pp. 840.

[Steigerwald-8] Steigerwald, John (8. 8. 2011.). „NASA Researchers: DNA Building Blocks Can Be Made in Space”. NASA. Arhivirano iz originala na datum 2020-05-11. Pristupljeno 10. 8. 2011.

[DNA-9] ScienceDaily Staff (9. 8. 2011.). „DNA Building Blocks Can Be Made in Space, NASA Evidence Suggests”. ScienceDaily. Pristupljeno 9. 8. 2011.

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