Adiponektin

ADIPOQ
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4DOU
Identifikatori
Aliasi	ADIPOQ
Vanjski ID-jevi	OMIM: 605441 MGI: 106675 HomoloGene: 3525 GeneCards: ADIPOQ
Lokacija gena (čovjek) Hrom. Hromosom 3 (čovjek)[1] Bend 3q27.3 Početak 186,842,704 bp[1] Kraj 186,858,463 bp[1]
Lokacija gena (miš) Hrom. Hromosom 16 (miš)[2] Bend 16 B1|16 13.96 cM Početak 22,965,286 bp[2] Kraj 22,976,778 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • hormone activity • signaling receptor binding • cytokine activity • sialic acid binding • protein homodimerization activity • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina • extracellular matrix structural constituent Ćelijska komponenta • cell surface • Endoplazmatski retikulum • collagen • Vanćelijsko • extracellular region • GO:0009327 makromolekulani kompleks • collagen-containing extracellular matrix Biološki proces • positive regulation of glucose import • positive regulation of protein phosphorylation • negative regulation of receptor binding • low-density lipoprotein particle clearance • negative regulation of blood pressure • negative regulation of macrophage differentiation • negative regulation of synaptic transmission • generation of precursor metabolites and energy • cellular response to epinephrine stimulus • negative regulation of gluconeogenesis • regulation of glucose metabolic process • Jednodnevni biološki ritam • fatty acid oxidation • positive regulation of interleukin-8 production • glucose metabolic process • protein heterotrimerization • negative regulation of heterotypic cell-cell adhesion • response to ethanol • negative regulation of inflammatory response • cellular response to cAMP • positive regulation of protein kinase A signaling • negative regulation of platelet-derived growth factor receptor signaling pathway • positive regulation of signal transduction • GO:0051247, GO:0051200 positive regulation of protein metabolic process • negative regulation of fat cell differentiation • response to linoleic acid • detection of oxidative stress • glucose homeostasis • adiponectin-activated signaling pathway • response to tumor necrosis factor • positive regulation of blood pressure • response to nutrient levels • positive regulation of cholesterol efflux • negative regulation of MAP kinase activity • cellular response to insulin stimulus • positive regulation of peptidyl-tyrosine phosphorylation • fatty acid beta-oxidation • negative regulation of tumor necrosis factor production • protein localization to plasma membrane • negative regulation of hormone secretion • protein homooligomerization • response to sucrose • positive regulation of metanephric glomerular visceral epithelial cell development • positive regulation of renal albumin absorption • negative regulation of granulocyte differentiation • response to nutrient • negative regulation of protein autophosphorylation • negative regulation of intracellular protein transport • membrane depolarization • response to glucose • positive regulation of myeloid cell apoptotic process • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of metanephric mesenchymal cell migration • negative regulation of cell migration • positive regulation of fatty acid metabolic process • brown fat cell differentiation • positive regulation of cAMP-dependent protein kinase activity • positive regulation of glycogen (starch) synthase activity • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of DNA biosynthetic process • positive regulation of protein kinase activity • response to hypoxia • negative regulation of phagocytosis • membrane hyperpolarization • negative regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of monocyte chemotactic protein-1 production • response to glucocorticoid • response to activity • negative regulation of platelet-derived growth factor receptor-alpha signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of ERK1 and ERK2 cascade • negative regulation of macrophage derived foam cell differentiation • regulation of fatty acid biosynthetic process • regulation of signaling receptor activity • negative regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell migration • response to bacterium • positive regulation of cold-induced thermogenesis • negative regulation of cold-induced thermogenesis • GO:0072468 Transdukcija signala Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9370	11450
Ensembl	ENSG00000181092	ENSMUSG00000022878
UniProt	Q15848	Q60994
RefSeq (mRNK)	NM_001177800 NM_004797	NM_009605
RefSeq (bjelančevina)	NP_001171271 NP_004788	NP_033735
Lokacija (UCSC)	Chr 3: 186.84 – 186.86 Mb	Chr 16: 22.97 – 22.98 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Adiponektin (sa skraćenicama GBP-28, apM1, AdipoQ and Acrp30) je proteinski hormon i adipokin, koji je uključen u regulaciju razine glukoze, kao i razgradnje masnih kiselina. Kod ljudi ga kodira gen ADIPOQ, a proizvodi se prvenstveno u masnom tkivu, ali i u mišićima, pa čak i u mozgu.^[5][6]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000181092 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000022878 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K (april 1996). "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)". Biochemical and Biophysical Research Communications. 221 (2): 286–9. doi:10.1006/bbrc.1996.0587. PMID 8619847.
6. ^ Martinez-Huenchullan SF, Tam CS, Ban LA, Ehrenfeld-Slater P, Mclennan SV, Twigg SM (2020). "Skeletal muscle adiponectin induction in obesity and exercise". Metabolism: Clinical and Experimenta. 102: 154008. doi:10.1016/j.metabol.2019.154008. PMID 31706980.