CD4

CD4
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1Q68, 1RZJ, 1RZK, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT, 2KLU, 2NXY, 2NXZ, 2NY0, 2NY1, 2NY2, 2NY3, 2NY4, 2NY5, 2NY6, 2QAD, 3B71, 3CD4, 3JWD, 3JWO, 3LQA, 3O2D, 3S5L, 3T0E, 4JM2, 1WBR, 3S4S, 4H8W, 4P9H, 4Q6I, 4R2G, 4R4H, 4RQS, 3J70, 5A7X, 5A8H, 5CAY
Identifiants
Aliases	CD4
IDs externes	OMIM: 186940 MGI: 88335 HomoloGene: 513 GeneCards: CD4
Position du gène (Homme)
Chr.	Chromosome 12 humain
Fin	6,820,799 bp
Position du gène (Souris)
Chr.	Chromosome 6 (souris)
Fin	124,865,184 bp
Expression génétique
	Fortement exprimé dans
	granulocyte; ; monocyte; ; ganglion lymphatique; ; rate; ; appendice iléo-cæcal; ; vésicule biliaire; ; thymus; ; upper lobe of left lung; ; poumon droit; ; right lobe of liver;
	Fortement exprimé dans
	thymus; ; ganglion lymphatique; ; ganglion mésentérique; ; sang; ; rate; ; zygote; ; artère carotide externe; ; artère carotide interne; ; gyrus frontal supérieur; ; molaire;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	transmembrane signaling receptor activity; virus receptor activity; protein homodimerization activity; zinc ion binding; extracellular matrix structural constituent; liaison enzymatique; immunoglobulin binding; liaison protéique; coreceptor activity; interleukin-16 binding; interleukin-16 receptor activity; MHC class II protein binding; identical protein binding; protein tyrosine kinase binding; signaling receptor activity; protein kinase binding; signaling receptor binding;
Composant cellulaire	endoplasmic reticulum lumen; integral component of membrane; early endosome; membrane; surface cellulaire; membrane du réticulum endoplasmique; radeau lipidique; T cell receptor complex; external side of plasma membrane; membrane plasmique; clathrin-coated vesicle membrane; integral component of plasma membrane;
Processus biologique	transmembrane receptor protein tyrosine kinase signaling pathway; defense response to Gram-negative bacterium; positive regulation of protein kinase activity; mitigation of host defenses by virus; positive regulation of calcium-mediated signaling; transduction de signal; helper T cell enhancement of adaptive immune response; T cell selection; response to estradiol; induction by virus of host cell-cell fusion; adaptive immune response; response to vitamin D; T cell differentiation; cell surface receptor signaling pathway; positive regulation of T cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; enzyme linked receptor protein signaling pathway; T cell activation; positive regulation of T cell activation; maintenance of protein location in cell; cytokine production; T cell receptor signaling pathway; processus du système immunitaire; positive regulation of calcium ion transport into cytosol; regulation of T cell activation; réponse immunitaire; adhésion cellulaire; viral process; fusion of virus membrane with host plasma membrane; organisation d'une membrane; positive regulation of protein phosphorylation; positive regulation of kinase activity; interleukin-15-mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of monocyte differentiation; régulation positive de la transcription dépendante de l'ADN; positive regulation of viral entry into host cell; regulation of calcium ion transport; positive regulation of ERK1 and ERK2 cascade; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cytokine-mediated signaling pathway; macrophage differentiation;
	Sources:Amigo / QuickGO
Orthologues
	920
	12504
	ENSG00000010610
	ENSMUSG00000023274
	P01730
	P06332
NM_000616; NM_001195014; NM_001195015; NM_001195016; NM_001195017;
	NM_001382705; NM_001382706; NM_001382707; NM_001382714
	NM_013488
NP_000607; NP_001181943; NP_001181944; NP_001181945; NP_001181946;
	NP_001369634; NP_001369635; NP_001369636; NP_001369643
	NP_038516
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

CD4 (cluster de différenciation 4) est une glycoprotéine exprimée à la surface des lymphocytes T CD4+, des cellules régulatrices T, des monocytes, des macrophages et de certaines cellules dendritiques.

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000010610 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000023274 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000010610 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000023274 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

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CD4

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