Ceruloplazmin

CP
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1KCW, 2J5W, 4EJX, 4ENZ
Identifikatori
Aliasi	CP
Vanjski ID-jevi	OMIM: 117700 MGI: 88476 HomoloGene: 75 GeneCards: CP
EC broj	1.16.3.1
Lokacija gena (čovjek) Hrom. Hromosom 3 (čovjek)[1] Bend 3q24-q25.1 Početak 149,162,410 bp[1] Kraj 149,221,829 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3|3 A2 Početak 20,011,218 bp[2] Kraj 20,063,309 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • chaperone binding • vezivanje iona metala • ferroxidase activity • oxidoreductase activity • copper ion binding • oxidoreductase activity, acting on metal ions Ćelijska komponenta • blood microparticle • extracellular region • lysosomal membrane • Egzosom • Vanćelijsko • endoplasmic reticulum lumen • ćelijska membrana Biološki proces • ion transport • copper ion transport • cellular iron ion homeostasis • Posttranslacione modifikacije • GO:0015915 transport • iron ion transport • iron ion homeostasis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1356	12870
Ensembl	ENSG00000047457	ENSMUSG00000003617
UniProt	P00450	Q61147
RefSeq (mRNK)	NM_000096	NM_001042611 NM_001276248 NM_001276250 NM_007752 NM_001374677
RefSeq (bjelančevina)	NP_000087	NP_001263177 NP_001263179 NP_031778 NP_001361606
Lokacija (UCSC)	Chr 3: 149.16 – 149.22 Mb	Chr 3: 20.01 – 20.06 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ceruloplazmin jest feroksidazni enzim koji je kod ljudi kodiran genom CP sa hromosoma 3.^[5][6][7]

Ceruloplazmin je glavni protein koji prenosi bakar u krvi, a osim toga ima ulogu u metabolizmu željeza. Prvi put je opisan 1948.^[8] Drugi protein, hefestin, poznat je po svojoj homologiji sa ceruloplazminom, a takođe učestvuje u metabolizmu gvožđa i verovatno bakra.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000047457 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000003617 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Takahashi N, Ortel TL, Putnam FW (Jan 1984). "Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule". Proceedings of the National Academy of Sciences of the United States of America. 81 (2): 390–4. Bibcode:1984PNAS...81..390T. doi:10.1073/pnas.81.2.390. PMC 344682. PMID 6582496.
6. ^ Koschinsky ML, Funk WD, van Oost BA, MacGillivray RT (Jul 1986). "Complete cDNA sequence of human preceruloplasmin". Proceedings of the National Academy of Sciences of the United States of America. 83 (14): 5086–90. Bibcode:1986PNAS...83.5086K. doi:10.1073/pnas.83.14.5086. PMC 323895. PMID 2873574.
7. ^ Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (maj 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular Genetics. 13 (3): 285–92. doi:10.1007/BF01535211. PMID 3474786. S2CID 45686258.
8. ^ Holmberg CG, Laurell CB (1948). "Investigations in serum copper. II. Isolation of the Copper containing protein, and a description of its properties". Acta Chem Scand. 2: 550–56. doi:10.3891/acta.chem.scand.02-0550.