Back ساركوما دبقية Arabic Gliosarkom Czech Gliosarkom German Gliosarcoma Spanish Gliosarcoma Italian
| Gliosarcoma | |
|---|---|
| Other names | Sarcomatous glioblastoma [1] |
 | |
| Micrograph showing a gliosarcoma. Elastic van Gieson's stain. | |
| Specialty | Neuro-oncology |
| Usual onset | Between 40 and 60 years old[2] |
| Prognosis | Five-year survival rate: 5.6%[2] |
| Frequency | ~215 new diagnoses per year (United States)[2] |
Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain cells, as opposed to the neural brain cells. Gliosarcoma is a malignant cancer, and is defined as a glioblastoma consisting of gliomatous and sarcomatous components.[3] Primary gliosarcoma (PGS) is classified as a grade IV tumor and a subtype of glioblastoma multiforme in the 2007 World Health Organization classification system (GBM).[4] Because of a lack of specific and clear diagnostic criteria, the word "gliosarcoma" was frequently used to refer to glial tumours with mesenchymal properties,[5] such as the ability to make collagen and reticulin.[6]
It is estimated that approximately 2.1% of all glioblastomas are gliosarcomas. Although most gliomas rarely show metastases outside the cerebrum, gliosarcomas have a propensity to do so, most commonly spreading through the blood to the lungs, and also liver and lymph nodes.[7]
They most commonly present in the temporal lobe[8][9] and frontal lobe.[10]
- ^ "Gliosarcoma: Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Archived from the original on 13 July 2019. Retrieved 13 July 2019.
- ^ a b c "Gliosarcoma Diagnosis and Treatment". National Cancer Institute. 17 September 2018. Archived from the original on October 11, 2021. Retrieved March 8, 2023.
- ^ Ayadi L, Charfi S, Khabir A, Kalle R, Sellami A, Makni S, et al. (March 2010). "[Cerebral gliosarcoma: clinico-pathologic study of 8 cases]". La Tunisie Médicale (in French). 88 (3): 142–146. PMID 20415184.
- ^ Louis D, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109
- ^ Stroebe H (1895) Ueber Entstehung und Bau der Gehirnglioma. Beitr Pathol Anat Allg Pathol 19:405–486
- ^ Feigin I, Gross SW (1954) Sarcoma arising in glioblastoma of the brain. Am J Pathol 31:633–653
- ^ Beaumont TL, Kupsky WJ, Barger GR, Sloan AE (May 2007). "Gliosarcoma with multiple extracranial metastases: case report and review of the literature". Journal of Neuro-Oncology. 83 (1): 39–46. doi:10.1007/s11060-006-9295-x. PMID 17171442. S2CID 13171064.
- ^ Galanis E, Buckner JC, Dinapoli RP, Scheithauer BW, Jenkins RB, Wang CH, O’Fallon JR, Farr G Jr (1998) Clinical outcome of gliosarcoma compared with glioblastoma multiforme: north central cancer treatment group results. J Neurosurg 89:425–430
- ^ Parekh H, O’Donovan DG, Sharma RR, Keogh AJ (1995) Primary cerebral gliosarcoma: report of 17 cases. Br J Neurosurg 9:171–178
- ^ Meis J, Martz KL, Nelson JS (1990) Mixed glioblastoma multiforme and sarcoma: a clinicopathologic study of 26 radiation therapy oncology group cases. Cancer 67:2342–2349