HMGCR

HMGCR
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DQ8, 1DQ9, 1DQA, 1HW8, 1HW9, 1HWI, 1HWJ, 1HWK, 1HWL, 2Q1L, 2Q6B, 2Q6C, 2R4F, 3BGL, 3CCT, 3CCW, 3CCZ, 3CD0, 3CD5, 3CD7, 3CDA, 3CDB
Dynodwyr
Cyfenwau	HMGCR, HMG-CoA reductase, Entrez 3156, LDLCQ3, 3-hydroxy-3-methylglutaryl-CoA reductase, Hydroxymethylglutaryl-CoA reductase
Dynodwyr allanol	OMIM: 142910 HomoloGene: 30994 GeneCards: HMGCR
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0050229 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; • protein homodimerization activity; • hydroxymethylglutaryl-CoA reductase (NADPH) activity; • GO:0001948, GO:0016582 protein binding; • NADP binding; • NADPH binding; • oxidoreductase activity; • protein phosphatase 2A binding;
Cydrannau o'r gell	• integral component of membrane; • endoplasmic reticulum membrane; • bilen; • intracellular membrane-bounded organelle; • peroxisomal membrane; • Reticwlwm endoplasmig;
Prosesau biolegol	• visual learning; • steroid metabolic process; • sterol biosynthetic process; • negative regulation of striated muscle cell apoptotic process; • coenzyme A metabolic process; • response to nutrient; • positive regulation of skeletal muscle tissue development; • lipid metabolism; • positive regulation of cardiac muscle cell apoptotic process; • negative regulation of insulin secretion involved in cellular response to glucose stimulus; • GO:0010260 heneiddio; • negative regulation of apoptotic process; • cholesterol metabolic process; • protein tetramerization; • isoprenoid biosynthetic process; • negative regulation of MAP kinase activity; • positive regulation of cell population proliferation; • positive regulation of ERK1 and ERK2 cascade; • negative regulation of wound healing; • ubiquinone metabolic process; • myoblast differentiation; • response to ethanol; • positive regulation of stress-activated MAPK cascade; • positive regulation of smooth muscle cell proliferation; • steroid biosynthetic process; • regulation of lipid metabolic process; • regulation of cholesterol biosynthetic process; • cholesterol biosynthetic process; • GO:1903363 negative regulation of protein catabolic process; • negative regulation of protein secretion; • negative regulation of amyloid-beta clearance;
	Sources:Amigo / QuickGO
Orthologau
	3156
	n/a
	ENSG00000113161
	n/a
	P04035
	n/a
	NM_000859; NM_001130996; NM_001364187
	n/a
	NP_000850; NP_001124468; NP_001351116; NP_000850.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HMGCR yw HMGCR a elwir hefyd yn 3-hydroxy-3-methylglutaryl-coenzyme A reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase , 3-hydroxy-3-methylglutaryl-CoA reductase a 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q13.3.^[2]

[1] "Human PubMed Reference:".

[2] HMGCR - Cronfa NCBI

[1]

[2]

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HMGCR

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