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Kaspaza-10
| Kaspaza-10 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.63 | ||||||||
| CAS broj | 189088-85-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kaspaza-10 (EC 3.4.22.63, FLICE2, Mch4, CASP-10, ICE-slična apoptotička proteaza 4, apoptotička proteaza Mch-4) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence Leu-Gln-Thr-Asp-Gly
Kaspaza-10 je inicijatorna kaspaza, koji što su i kaspaza-2 (EC 3.4.22.55), kaspaza-8 (EC 3.4.22.61) i kaspaza-9 (EC 3.4.22.62).
- ^ Chang, H.Y. & Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821—846. PMID 11104820.
- ^ Fischer, U., Stroh, C. and Schulze-Osthoff, K. (2006). „Unique and overlapping substrate specificities of caspase-8 and caspase-10”. Oncogene. 25: 152—159. PMID 16186808.
- ^ Shikama, Y., Yamada, M. and Miyashita, T. (2003). „Caspase-8 and caspase-10 activate NF-κB through RIP, NIK and IKKα kinases”. Eur. J. Immunol. 33: 1998—2006. PMID 12884866.
- ^ Boatright, K.M., Deis, C., Denault, J.B., Sutherlin, D.P. and Salvesen, G.S. (2004). „Activation of caspases-8 and -10 by FLIPL”. Biochem. J. 382: 651—657. PMID 15209560.
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