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MreB
 | This article includes a list of general references, but it lacks sufficient corresponding inline citations. (August 2019) |
| Cell shape determining protein MreB/Mbl | |||||||||
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| Identifiers | |||||||||
| Symbol | MreB | ||||||||
| Pfam | PF06723 | ||||||||
| InterPro | IPR004753 | ||||||||
| CDD | cd10225 | ||||||||
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MreB is a protein found in bacteria that has been identified as a homologue of actin, as indicated by similarities in tertiary structure and conservation of active site peptide sequence. The conservation of protein structure suggests the common ancestry of the cytoskeletal elements formed by actin, found in eukaryotes, and MreB, found in prokaryotes.[1] Indeed, recent studies have found that MreB proteins polymerize to form filaments that are similar to actin microfilaments. It has been shown to form multilayer sheets comprising diagonally interwoven filaments in the presence of ATP or GTP.[2]
MreB along with MreC and MreD are named after the mre operon (murein formation gene cluster E) to which they all belong.[3]
- ^ Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC (June 2015). "The evolution of compositionally and functionally distinct actin filaments". Journal of Cell Science. 128 (11): 2009–2019. doi:10.1242/jcs.165563. PMID 25788699.
- ^ Popp D, Narita A, Maeda K, Fujisawa T, Ghoshdastider U, Iwasa M, et al. (May 2010). "Filament structure, organization, and dynamics in MreB sheets". The Journal of Biological Chemistry. 285 (21): 15858–15865. doi:10.1074/jbc.M109.095901. PMC 2871453. PMID 20223832.
- ^ Löwe, Jan; Amos, Linda A. (2017-05-11). Prokaryotic Cytoskeletons: Filamentous Protein Polymers Active in the Cytoplasm of Bacterial and Archaeal Cells. Springer. p. 255. ISBN 978-3-319-53047-5.
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