Pax6

PAX6
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	2CUE, 6PAX
Identifiants
Aliases	PAX6
IDs externes	OMIM: 607108 MGI: 97490 HomoloGene: 1212 GeneCards: PAX6
Position du gène (Homme)
Chr.	Chromosome 11 humain
Fin	31,818,062 bp
Position du gène (Souris)
Chr.	Chromosome 2 (souris)
Fin	105,527,709 bp
Expression génétique
	Fortement exprimé dans
	palpebral conjunctiva; ; ventricular zone; ; cellule bêta; ; paraflocculus of cerebellum; ; éminence ganglionnaire; ; Vermis du cervelet; ; right hemisphere of cerebellum; ; pont; ; external globus pallidus; ; Region I of hippocampus proper;
	Fortement exprimé dans
	neural layer of retina; ; corneal stroma; ; ventricular zone; ; cristallin; ; épithélium cornéen; ; iris; ; epithelium of lens; ; îlot de Langerhans; ; corps ciliaire; ; conjunctival fornix;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison protéique; liaison ADN; sequence-specific DNA binding; ubiquitin-protein transferase activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; liaison de chromatine; DNA-binding transcription factor activity; transcription factor binding; protein kinase binding; ubiquitin protein ligase binding; liaison d'histone acétyltransférase; co-SMAD binding; R-SMAD binding; HMG box domain binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Composant cellulaire	cytoplasme; noyau; nucléoplasme; cytosol; intracellulaire;
Processus biologique	développement de l'œil; blood vessel development; morphogenèse d'un organe animal; regulation of transcription, DNA-templated; glucose homeostasis; transcription, DNA-templated; central nervous system development; response to wounding; différenciation cellulaire; cornea development in camera-type eye; negative regulation of neurogenesis; vue; iris morphogenesis; développent d'un organisme multicellulaire; neuron fate commitment; Ubiquitination; negative regulation of transcription by RNA polymerase II; establishment of mitotic spindle orientation; cell fate determination; migration d'un neurone; negative regulation of protein phosphorylation; positive regulation of neuroblast proliferation; lens development in camera-type eye; régionalisation; type B pancreatic cell differentiation; pancreatic A cell development; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; hedgehog; axonogenesis; Guidage axonal; développement cérébral; salivary gland morphogenesis; negative regulation of cell population proliferation; regulation of asymmetric cell division; dorsal/ventral axis specification; anterior/posterior pattern specification; dorsal/ventral pattern formation; régulation de l'expression des gènes; positive regulation of gene expression; pallium development; oligodendrocyte cell fate specification; cerebral cortex regionalization; forebrain dorsal/ventral pattern formation; commitment of neuronal cell to specific neuron type in forebrain; forebrain-midbrain boundary formation; telencephalon regionalization; pituitary gland development; habenula development; signal transduction involved in regulation of gene expression; keratinocyte differentiation; regulation of cell migration; positive regulation of epithelial cell differentiation; forebrain development; lacrimal gland development; protein localization to organelle; eye photoreceptor cell development; camera-type eye development; cell fate commitment; negative regulation of neuron differentiation; régulation positive de la transcription dépendante de l'ADN; positive regulation of transcription by RNA polymerase II; regulation of timing of cell differentiation; embryonic camera-type eye morphogenesis; astrocyte differentiation; negative regulation of epithelial cell proliferation; régulation de la neurogenèse; retina development in camera-type eye; cellular response to leukemia inhibitory factor; negative regulation of neural precursor cell proliferation; positive regulation of core promoter binding;
	Sources:Amigo / QuickGO
Orthologues
	5080
	18508
	ENSG00000007372
	ENSMUSG00000027168
	P26367
	P63015
NM_000280; NM_001127612; NM_001258462; NM_001258463; NM_001258464;
	NM_001258465; NM_001310158; NM_001310159; NM_001310160; NM_001310161; NM_001604
NM_001244198; NM_001244200; NM_001244201; NM_001244202; NM_013627;
	NM_001310144; NM_001310145; NM_001310146
NP_000271; NP_001121084; NP_001245391; NP_001245392; NP_001245393;
	NP_001245394; NP_001297087; NP_001297088; NP_001297089; NP_001297090; NP_001595; NP_001355816; NP_001355817; NP_001355818; NP_001355819; NP_001355820; NP_001355821; NP_001355822; NP_001355823; NP_001355828; NP_001355829; NP_001355830; NP_001355831; NP_001355832; NP_001355833; NP_001355834; NP_001355835; NP_001355836; NP_001355837; NP_001355838; NP_001355839; NP_001355840; NP_001355841; NP_001355842; NP_001355843; NP_001355844; NP_001355845; NP_001355846; NP_001355847; NP_001355848; NP_001355849; NP_001355850; NP_001355851; NP_001355852; NP_001355853; NP_001355854; NP_001355855; NP_001355856; NP_001355857; NP_001355858; NP_001355859
NP_001231127; NP_001231129; NP_001231130; NP_001231131; NP_001297073;
	NP_001297074; NP_001297075; NP_038655
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

La protéine paired box 6 (Pax6) est un facteur de transcription notamment impliqué dans le développement des yeux. Elle est codée par le gène PAX6 situé sur le chromosome 11 humain.

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000007372 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000027168 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000007372 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000027168 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

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