Perazine

Perazine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N05AB10 (WHO) ;
Identifiers
	IUPAC name 10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine;
CAS Number	84-97-9 ;
PubChem CID	4744;
DrugBank	DB12710 ;
ChemSpider	4582 ;
UNII	8915147A2B;
KEGG	C16903;
ChEBI	CHEBI:59118 ;
ChEMBL	ChEMBL1697766;
CompTox Dashboard (EPA)	DTXSID6048628 ;
ECHA InfoCard	100.001.435
Chemical and physical data
Formula	C20H25N3S
Molar mass	339.50 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=CC=CC=C42;
	InChI InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3 ; Key:WEYVCQFUGFRXOM-UHFFFAOYSA-N ;
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Perazine (Taxilan) is a moderate-potency typical antipsychotic of the phenothiazine class. It is quite similar to chlorpromazine, and acts as a dopamine antagonist. It was very popular in West-Germany. A 2014 systematic review compared it with other antipsychotic drugs:

Perazine versus other antipsychotic drugs for schizophrenia^[1]

Summary

The number, size and reporting of randomized controlled perazine trials are insufficient to present firm conclusions about the properties of this antipsychotic. It is possible that perazine is associated with a similar risk of extrapyramidal side effects as some atypical antipsychotics but this is based on few comparisons of limited power.^[1]

Outcome	Findings in words	Findings in numbers	Quality of evidence
Global state
No better or deterioration Follow-up: average 5 weeks	Perazine may decrease the chance of experiencing this outcome. These findings are based on data of low quality.	RR 0.43 (0.23 to 0.81)	Low
Mental state
Less than 30% BPRS reduction Follow-up: mean 5 weeks	The average overall mental state score in the perazine group was lower than for those given other antipsychotic drugs but the difference between the groups was not clear. These findings are based on data of low quality.	RR 0.82 (0.61 to 1.09)	Low
Adverse effects
Needing antiparkinson medication Follow-up: average 5 weeks	Perazine might increase the risk of experiencing this outcome but at present it is not possible to be confident about the difference between perazine and other antipsychotic drugs. Data supporting this finding are very limited.	RR 4.5 (1.04 to 19.45)	Very low
Leaving the study early - due to adverse events Follow-up: average 4 weeks	There was not a clear difference between perazine and the other antipsychotic drugs for this general outcome reflecting overall adverse event 'load'. These findings are based on data of low quality.	0.87 (0.4 to 1.9)	Low
Acceptability of treatment
Leaving the studies early - any reason Follow-up: 5 weeks	Perazine and the comparison antipsychotic drugs were equally tolerated. These findings are based on data of low quality.	RR 0.62 (0.35 to 1.1)	Low
	No study reported any data on outcomes such as quality of life or information relating to satisfaction with care.

^ ^a ^b Leucht S, Helfer B, Hartung B (January 2014). "Perazine for schizophrenia". The Cochrane Database of Systematic Reviews. 1 (1): CD002832. doi:10.1002/14651858.CD002832.pub3. PMC 11015532. PMID 24425538.

[Leu2014-1] Leucht S, Helfer B, Hartung B (January 2014). "Perazine for schizophrenia". The Cochrane Database of Systematic Reviews. 1 (1): CD002832. doi:10.1002/14651858.CD002832.pub3. PMC 11015532. PMID 24425538.

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