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Proinsulin
| insulin | |||||||
|---|---|---|---|---|---|---|---|
 Insulin undergoes extensive posttranslational modification along the production pathway. Production and secretion are largely independent; prepared insulin is stored awaiting secretion. Both C-peptide and mature insulin are biologically active. Cell components and proteins in this image are not to scale. | |||||||
| Identifiers | |||||||
| Symbol | INS | ||||||
| NCBI gene | 3630 | ||||||
| HGNC | 6081 | ||||||
| OMIM | 176730 | ||||||
| RefSeq | NM_000207 | ||||||
| UniProt | P01308 | ||||||
| Other data | |||||||
| Locus | Chr. 11 p15.5 | ||||||
| |||||||
Proinsulin is the prohormone precursor to insulin made in the beta cells of the Pancreatic Islets, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene.[1][2] The pancreatic islets only secrete between 1% and 3% of proinsulin intact.[3] However, because proinsulin has a longer half life than insulin, it can account for anywhere from 5–30% of the insulin-like structures circulating in the blood.[3] There are higher concentrations of proinsulin after meals and lower levels when a person is fasting.[3] Additionally, while proinsulin and insulin have structural differences, proinsulin does demonstrate some affinity for the insulin receptor. Due to the relative similarities in structure, proinsulin can produce between 5% and 10% of the metabolic activity similarly induced by insulin.[3]
Proinsulin is the final single chain protein structure secreted by cells before cleavage into mature insulin.[4] Proinsulin was discovered by Professor Donald F. Steiner of the University of Chicago in 1967.[5]
- ^ "Entrez Gene: INS insulin".
- ^ Bell GI, Pictet RL, Rutter WJ, Cordell B, Tischer E, Goodman HM (March 1980). "Sequence of the human insulin gene". Nature. 284 (5751): 26–32. Bibcode:1980Natur.284...26B. doi:10.1038/284026a0. PMID 6243748. S2CID 4363706.
- ^ a b c d "Interpretation for 80908 Proinsulin, Plasma". www.mayomedicallaboratories.com. Archived from the original on 2017-10-04. Retrieved 2017-03-09.
- ^ Assali NS, Clark KE, Zugaib M, Brinkman CR, Nuwayhid B (1995). "Effects of estrogenic hormones on uteroplacental hemodynamics and progesterone production in the sheep". International Journal of Fertility. 23 (3): 219–23. PMC 8333766. PMID 40897.
- ^ Philipson LH, Bell G, Polonsky KS (January 2015). "Donald F. Steiner MD, 1930-2014: discoverer of proinsulin". Proceedings of the National Academy of Sciences of the United States of America. 112 (4): 940–1. Bibcode:2015PNAS..112..940P. doi:10.1073/pnas.1423774112. PMC 4313841. PMID 25561547.
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