STAT1

STAT1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3WWT, 1BF5, 1YVL, 2KA6
Dynodwyr
Cyfenwau	STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
Dynodwyr allanol	OMIM: 600555 HomoloGene: 21428 GeneCards: STAT1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • protein homodimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0000983 RNA polymerase II general transcription initiation factor activity; • signal transducer activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • enzyme binding; • tumor necrosis factor receptor binding; • double-stranded DNA binding; • RNA polymerase II core promoter sequence-specific DNA binding; • cadherin binding; • histone acetyltransferase binding; • GO:0031493 histone binding; • ubiquitin-like protein ligase binding; • promoter-specific chromatin binding; • sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • CCR5 chemokine receptor binding; • protein phosphatase 2A binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • nucleoplasm; • nucleolus; • perinuclear region of cytoplasm; • cnewyllyn cell; • cytosol; • axon; • dendrite; • GO:0009327 protein-containing complex;
Prosesau biolegol	• regulation of apoptotic process; • metanephric mesenchymal cell proliferation involved in metanephros development; • GO:0009373 regulation of transcription, DNA-templated; • cellular response to interferon-beta; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; • metanephric mesenchymal cell differentiation; • tumor necrosis factor-mediated signaling pathway; • GO:1901227 negative regulation of transcription by RNA polymerase II; • renal tubule development; • response to interferon-beta; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • transcription, DNA-templated; • negative regulation of endothelial cell proliferation; • regulation of type I interferon-mediated signaling pathway; • regulation of interferon-gamma-mediated signaling pathway; • positive regulation of mesenchymal cell proliferation; • negative regulation of metanephric nephron tubule epithelial cell differentiation; • negative regulation of angiogenesis; • negative regulation by virus of viral protein levels in host cell; • GO:0022415 viral process; • endothelial cell migration; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0072468 signal transduction; • macrophage derived foam cell differentiation; • positive regulation of erythrocyte differentiation; • type I interferon signaling pathway; • cellular response to interferon-gamma; • positive regulation of defense response to virus by host; • positive regulation of interferon-alpha production; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • defense response to virus; • interferon-gamma-mediated signaling pathway; • receptor signaling pathway via JAK-STAT; • response to nutrient; • blood circulation; • positive regulation of cell population proliferation; • response to mechanical stimulus; • GO:1904578 response to organic cyclic compound; • cellular response to insulin stimulus; • response to cytokine; • response to hydrogen peroxide; • response to peptide hormone; • positive regulation of smooth muscle cell proliferation; • response to cAMP; • positive regulation of nitric-oxide synthase biosynthetic process; • cellular response to cytokine stimulus; • GO:1904579 cellular response to organic cyclic compound; • positive regulation of transcription of Notch receptor target; • cytokine-mediated signaling pathway; • interleukin-21-mediated signaling pathway; • interleukin-6-mediated signaling pathway; • interleukin-27-mediated signaling pathway; • interleukin-35-mediated signaling pathway; • interleukin-9-mediated signaling pathway; • defense response; • regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologau
	6772
	n/a
	ENSG00000115415
	n/a
	P42224
	n/a
	NM_007315; NM_139266
	n/a
	NP_009330; NP_644671
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn STAT1 yw STAT1 a elwir hefyd yn Signal transducer and activator of transcription 1-alpha/beta a Signal transducer and activator of transcription 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q32.2.^[2]

[1] "Human PubMed Reference:".

[2] STAT1 - Cronfa NCBI

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