STAT1

STAT1
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 3WWT、​1BF5、​1YVL、​2KA6
識別號
别名	STAT1；, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
外部ID	OMIM：600555 MGI：103063 HomoloGene：21428 GeneCards：STAT1
相關疾病
慢性黏膜皮膚念珠菌病、​susceptibility to viral and mycobacterial infections[1]
基因位置（人类） 染色体 2號染色體[2] 基因座 2q32.2 起始 190,908,460 bp[2] 终止 191,020,960 bp[2]
基因位置（小鼠） 染色体 小鼠1号染色体[3] 基因座 1 C1.1|1 26.81 cM 起始 52,158,599 bp[3] 终止 52,201,024 bp[3]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • DNA结合 • protein homodimerization activity • DNA结合转录因子活性 • RNA polymerase II general transcription initiation factor activity • signal transducer activity • RNA polymerase II cis-regulatory region sequence-specific DNA binding • 血浆蛋白结合 • 相同蛋白质结合 • 酶结合 • tumor necrosis factor receptor binding • double-stranded DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • cadherin binding • histone acetyltransferase binding • histone binding • ubiquitin-like protein ligase binding • promoter-specific chromatin binding • sequence-specific DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • CCR5 chemokine receptor binding • protein phosphatase 2A binding • DNA-binding transcription activator activity, RNA polymerase II-specific 細胞組分 • 細胞質 • 核质 • 核仁 • 细胞质的核周区域 • 细胞核 • 细胞质基质 • 轴突 • 树突 • 大分子复合体 生物學過程 • regulation of apoptotic process • metanephric mesenchymal cell proliferation involved in metanephros development • regulation of transcription, DNA-templated • cellular response to interferon-beta • regulation of transcription by RNA polymerase II • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • metanephric mesenchymal cell differentiation • tumor necrosis factor-mediated signaling pathway • negative regulation of transcription by RNA polymerase II • renal tubule development • response to interferon-beta • negative regulation of I-kappaB kinase/NF-kappaB signaling • transcription, DNA-templated • negative regulation of endothelial cell proliferation • regulation of type I interferon-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • positive regulation of mesenchymal cell proliferation • negative regulation of metanephric nephron tubule epithelial cell differentiation • negative regulation of angiogenesis • negative regulation by virus of viral protein levels in host cell • viral process • endothelial cell migration • positive regulation of transcription by RNA polymerase II • 訊息傳遞 • macrophage derived foam cell differentiation • positive regulation of erythrocyte differentiation • type I interferon signaling pathway • cellular response to interferon-gamma • positive regulation of defense response to virus by host • positive regulation of interferon-alpha production • positive regulation of transcription, DNA-templated • defense response to virus • interferon-gamma-mediated signaling pathway • receptor signaling pathway via JAK-STAT • response to nutrient • blood circulation • positive regulation of cell population proliferation • response to mechanical stimulus • response to organic cyclic compound • cellular response to insulin stimulus • response to cytokine • response to hydrogen peroxide • response to peptide hormone • positive regulation of smooth muscle cell proliferation • response to cAMP • positive regulation of nitric-oxide synthase biosynthetic process • cellular response to cytokine stimulus • cellular response to organic cyclic compound • positive regulation of transcription of Notch receptor target • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • interleukin-6-mediated signaling pathway • interleukin-27-mediated signaling pathway • interleukin-35-mediated signaling pathway • interleukin-9-mediated signaling pathway • defense response • regulation of cell population proliferation Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	6772	20846
Ensembl	ENSG00000115415	ENSMUSG00000026104
UniProt	P42224	P42225
mRNA​序列	​NM_007315 ​NM_139266	NM_001205313 ​NM_001205314 ​NM_009283 ​NM_001357627
蛋白序列	NP_009330 ​NP_644671	无数据
基因位置​（UCSC）	Chr 2: 190.91 – 191.02 Mb	Chr 1: 52.16 – 52.2 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

STAT1是转录因子中信号转导及转录激活蛋白（STAT蛋白）家族的一员。

STAT1涉及I型、II型或III型干扰素激活基因的正调控。在干扰素-γ刺激下，STAT1会组成同源二聚体或与STAT3组成异二聚体结合到GAS（Interferon-Gamma-Activated Sequence，干扰素γ激活序列）启动子上；而在干扰素-α或干扰素-β刺激下，STAT1会与STAT2组成异二聚体结合到ISRE（Interferon-Stimulated Response Element，干扰素激活反应元件）启动子上^[6]。在这两种情况下，STAT二聚体与启动子的结合都会导致ISG（Interferon-Stimulated Genes，干扰素激活基因）的表达。

STAT1可由二烯丙基二硫诱导表达^[7]

1. ^ 與STAT1相關的疾病；在維基數據上查看/編輯參考. 
2. ^ ^{2.0 2.1 2.2} GRCh38: Ensembl release 89: ENSG00000115415 - Ensembl, May 2017
3. ^ ^{3.0 3.1 3.2} GRCm38: Ensembl release 89: ENSMUSG00000026104 - Ensembl, May 2017
4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
6. ^ Michael G. Katze; Yupeng He & Michael Gale; et al. Viruses and interferon: a fight for supremacy. Nature Reviews Immunology. 2002, 2 (9): 675–87. PMID 12209136. doi:10.1038/nri888. 
7. ^ Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG. Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR. Cancer Genomics Proteomics. 2007, 4 (2): 93–7. PMID 17804871.