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Stromelizin-1
| Stromelizin-1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.17 | ||||||||
| CAS broj | 79955-99-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Stromelizin-1 (EC 3.4.24.17, matriks metaloproteinaza 3, proteoglikanaza, kolagenaza aktivacinog protein, prokolagenazni aktivator, tranzin, MMP-3, neutralna proteoglikanaza, stromelizin, kolagen-aktivirajući protein) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Preferentno razlaganje na mestima gde su P1', P2' i P3' hidrofobni ostaci
Ova ekstracelularna endopeptidaza je prisutna u tkivu kičmenjaka.
- ↑ Chin, J.R., Murphy, G. and Werb, Z. (1985). „Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates”. J. Biol. Chem. 260: 12367-12376. PMID 2995374.
- ↑ Okada, Y., Nagase, H. and Harris, E.D., Jr. (1986). „A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization”. J. Biol. Chem. 261: 14245-14255. PMID 3095317.
- ↑ Docherty, A.J.P. and Murphy, G. (1990). „The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins”. Ann. Rheum. Dis. 49: 469-479. PMID 2197998.
- ↑ Emonard, H. and Grimaud, J.-A. (1990). „Matrix metalloproteinase. A review”. Cell. Mol. Biol. 36: 131-153. PMID 2165861.
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