T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene.[5][6] This gene is also known by several other names: T-Brain 1, TBR-1, TES-56, and MGC141978.[5] TBR1 is a member of the TBR1 subfamily of T-box family transcription factors, which share a common DNA-binding domain. Other members of the TBR1 subfamily include EOMES and TBX21. TBR1 is involved in the differentiation and migration of neurons and is required for normal brain development. TBR1 interacts with various genes and proteins in order to regulate cortical development, specifically within layer VI of the developing six-layered human cortex.[7] Studies show that TBR1 may play a role in major neurological diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and autism spectrum disorder (ASD).
- ^ a b c GRCh38: Ensembl release 89: ENSG00000136535 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035033 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: T-box, brain, 1". Retrieved 2011-11-01.
- ^ Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L, Rubenstein JL (Jul 1995). "T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex". Neuron. 15 (1): 63–78. doi:10.1016/0896-6273(95)90065-9. PMID 7619531.
- ^ Hsueh YP, Wang TF, Yang FC, Sheng M (Mar 2000). "Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2". Nature. 404 (6775): 298–302. Bibcode:2000Natur.404..298H. doi:10.1038/35005118. PMID 10749215. S2CID 4415747.