HBB

HBB
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 6HBW, 1A00, 1A01, 1A0U, 1A0Z, 1A3N, 1A3O, 1ABW, 1ABY, 1AJ9, 1B86, 1BAB, 1BBB, 1BIJ, 1BUW, 1BZ0, 1BZ1, 1BZZ, 1C7B, 1C7C, 1C7D, 1CBL, 1CBM, 1CH4, 1CLS, 1CMY, 1COH, 1DKE, 1DXT, 1DXU, 1DXV, 1FN3, 1G9V, 1GBU, 1GBV, 1GLI, 1GZX, 1HAB, 1HAC, 1HBA, 1HBB, 1HBS, 1HCO, 1HDB, 1HGA, 1HGB, 1HGC, 1HHO, 1IRD, 1J3Y, 1J3Z, 1J40, 1J41, 1J7S, 1J7W, 1J7Y, 1JY7, 1K0Y, 1K1K, 1KD2, 1LFL, 1LFQ, 1LFT, 1LFV, 1LFY, 1LFZ, 1LJW, 1M9P, 1MKO, 1NEJ, 1NIH, 1NQP, 1O1I, 1O1J, 1O1K, 1O1L, 1O1M, 1O1N, 1O1O, 1O1P, 1QI8, 1QSH, 1QSI, 1QXD, 1QXE, 1R1X, 1R1Y, 1RPS, 1RQ3, 1RQ4, 1RQA, 1RVW, 1SDK, 1SDL, 1THB, 1UIW, 1VWT, 1XXT, 1XY0, 1XYE, 1XZ2, 1XZ4, 1XZ5, 1XZ7, 1XZU, 1XZV, 1Y09, 1Y0A, 1Y0C, 1Y0D, 1Y0T, 1Y0W, 1Y22, 1Y2Z, 1Y31, 1Y35, 1Y45, 1Y46, 1Y4B, 1Y4F, 1Y4G, 1Y4P, 1Y4Q, 1Y4R, 1Y4V, 1Y5F, 1Y5J, 1Y5K, 1Y7C, 1Y7D, 1Y7G, 1Y7Z, 1Y83, 1Y85, 1Y8W, 1YDZ, 1YE0, 1YE1, 1YE2, 1YEN, 1YEO, 1YEQ, 1YEU, 1YEV, 1YFF, 1YG5, 1YGD, 1YGF, 1YH9, 1YHE, 1YHR, 1YIE, 1YIH, 1YVQ, 1YVT, 1YZI, 2D5Z, 2D60, 2DN1, 2DN2, 2DN3, 2DXM, 2H35, 2HBC, 2HBD, 2HBE, 2HBF, 2HBS, 2HCO, 2HHD, 2HHE, 2M6Z, 2W6V, 2W72, 2YRS, 3B75, 3D17, 3D7O, 3DUT, 3HXN, 3IC0, 3IC2, 3KMF, 3NL7, 3NMM, 3ODQ, 3ONZ, 3OO4, 3OO5, 3P5Q, 3QJB, 3QJC, 3QJD, 3QJE, 3R5I, 3S65, 3S66, 3SZK, 3W4U, 3WCP, 3WHM, 4FC3, 4HHB, 4IJ2, 4L7Y, 4M4A, 4M4B, 4MQC, 4MQG, 4MQH, 4MQI, 4N7N, 4N7O, 4N7P, 4N8T, 4NI0, 4NI1, 4ROL, 4ROM, 4WJG, 4X0L, 4XS0, 5E29, 5E6E, 5EE4, 5HU6, 5JDO, 5KDQ, 5E83
Identifikatori
Aliasi	HBB
Vanjski ID-jevi	OMIM: 141900 MGI: 5474850 HomoloGene: 68066 GeneCards: HBB
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11p15.4 Početak 5,225,464 bp[1] Kraj 5,229,395 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7 E3|7 Početak 103,461,731 bp[2] Kraj 103,463,203 bp[2]
Ontologija gena Molekularna funkcija • iron ion binding • oxygen binding • oxygen carrier activity • peroxidase activity • vezivanje iona metala • hemoglobin binding • GO:0001948, GO:0016582 vezivanje za proteine • heme binding • haptoglobin binding Ćelijska komponenta • citosol • endocytic vesicle lumen • blood microparticle • extracellular region • hemoglobin complex • Egzosom • haptoglobin-hemoglobin complex • tertiary granule lumen • ficolin-1-rich granule lumen • Vanćelijsko Biološki proces • positive regulation of cell death • protein heterooligomerization • nitric oxide transport • positive regulation of nitric oxide biosynthetic process • oxygen transport • Koagulacija (krv) • receptor-mediated endocytosis • regulation of blood pressure • bicarbonate transport • hydrogen peroxide catabolic process • platelet aggregation • response to hydrogen peroxide • renal absorption • cellular oxidant detoxification • neutrophil degranulation • GO:0015915 transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3043	101488143
Ensembl	ENSG00000244734	ENSMUSG00000073940
UniProt	P68871	P02088
RefSeq (mRNK)	NM_000518	NM_008220
RefSeq (bjelančevina)	NP_000509	NP_032246 NP_001188320 NP_001265090
Lokacija (UCSC)	Chr 11: 5.23 – 5.23 Mb	Chr 7: 103.46 – 103.46 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Hemoglobinska podjedinica beta, (beta globin, β-globin, hemoglobin beta) je globinski protein, koji je kodiran genom HBB. Zajedno sa alfa globinom (HBA), čini najčešći oblik hemoglobina kod odraslih ljudi, hemoglobin A (HbA).^[5] > Dug je 147 aminokiselina i ima molekulsku masu 15.867 Da. Normalni odrasli ljudski HbA je heterotetramer koji se sastoji od po dva alfa i beta lanca.

HBB je kodiran genom HBB na ljudskom hromozomu 11. Mutacije u genu proizvode nekoliko varijanti proteina koji su povezani s genetičkim poremećajima, kao što su bolest srpastih ćelija i beta talasemija, kao i korisne osobine poput genetička otpornost na malariju.^[6][7]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000244734 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000073940 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: HBB hemoglobin, beta".
6. ^ Sabeti, Pardis C (2008). "Natural selection: uncovering mechanisms of evolutionary adaptation to infectious disease". Nature Education. 1 (1): 13.
7. ^ Kwiatkowski DP (2005). "How malaria has affected the human genome and what human genetics can teach us about malaria". The American Journal of Human Genetics. 77 (2): 171–192. doi:10.1086/432519. PMC 1224522. PMID 16001361.